Industrial Technology Research Institute

Academia Sinica

Ting-Shou Chen

Chih-Hung Chen

Hui-Ping Tsai

Po-Ting Chen

On Lee

Hung-Chi Chien

Yi-Cheng Cheng

Tien-Soung Tong

Shu-Jiau Chiou

Yung-Feng Liao

Rita P-y Chen

Chang-Jen Huang

Cheng-Li Fang

Bo-Kai Wu

Hsin-Hsin Shen

Pei-Shin Jiang

Lain-Tze Lee

Cheng-Tai Chen

Chih-Peng Liu

Chrong-Shiong Hwang

Ying-Chu Shih

Yen-Chun Chen

Yuan-Jang Tsai

Chi-Y Hung

Kuei-Tai Lai

Yow-Lone Chang

Ling-Mei Wang

Jane S-c Tsai

Ching-Huai Ko

Lain-tze Lee

Rita P-Y Chen

Disclosed herein is the novel use of use of aspp. extract, which may upregulate neprilysin, induce autophagy, protect neuron from amyloidopathy or tauopathy, and/or promote neurite outgrowth, thus thespp. extract of the present disclosure may be used as a dietary supplement for the prophylaxis or treatment of amyloid related neurodegenerative diseases so as to ameliorate or alleviate symptoms associated with the amyloid related neurodegenerative diseases.

extract and uses thereof

A gold nanocluster composition and method for preparing the same are provided. The method includes providing a gold ion-containing solution. Next, the method entails mixing the gold ion-containing solution and a reducing agent solution to obtain a first mixture liquid, and heating the first mixture liquid to obtain a second mixture liquid, wherein the second mixture liquid contains the gold nanoclusters, which are partially capped by reducing agent.

Method for preparing gold nanocluster composition

An azaazulene compound is provided. The azaazulene compound has formula (I) shown below. Each variable in formula (I) is defined in the specification. The compound can be used to treat cancer. The invention also provides a method for treating cancer. The method includes administering to a subject in need thereof an effective amount of one or more azaazulene compounds of formula (I).

Azaazulene compounds

The invention is related to novel azulene-oxindole compounds having formula (I) shown below, wherein one of R, Rand Rrepresents a moiety of formula (II), each of Aand Aindependently is nitrogen, oxygen or sulfur, each of the others of R, R, R, R, R, R, R, R, R, R, R, R, R, and Ris as recited in the specification. The novel compound potentially inhibits multiple kinases and thus can be used to treat some disease like cancer or inflammatory. 

Azulene-oxindole compounds as multiple-kinase inhibitors and useful as anticancer agents

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Yangmei, Taiwan

Ting-Shou Chen