Atomic Energy Council-institute of Nuclear Energy Research

Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.o.c

Institute of Nuclear Energy Research

Institute of Nuclear Energy Research, Atomic Energy Council

Atomic Energy Council

Ting-Shien Duh

Wuu-Jyh Lin

Jenn-Tzong Chen

Mao-Hsung Chang

Li-Yuan Huang

Chien-Hsin Lu

Sun-Rong Huang

Ying-Ming Tsai

Dow-Che Chen

Kuo-Yuan Chu

Ming-Hsin Li

Chyng-Yann Shiue

Shiou-Shiow Farn

Hsin-Ell Wang

Yean-Hung Tu

Hao-Wen Kao

Wen-Chin Su

Yen-Hung Tu

Ping-Yen Huang

Wen-Yi Chang

Chuan-Lin Chen

Wei-Ming Li

Ying-Ming c/o Atomic En Council-Inst Of Nucl Energy Tsai

The preparation method of radiation-sensitive copolymer carrier for coating radiated nanoparticles and/or chemotherapy drugs includes forming a nanosphere by diselenide block copolymers and DSPE-PEG-biomarkers to coat chemotherapy drugs and/or radiated nanoparticles that can be released from the opened nanosphere by protons penetrating tissue during proton therapy. The treatment effect of proton therapy is enhanced by two ways of using the radiated nanoparticles released from an opened nanosphere to produce nuclear fission with the protons for releasing electrons to destroy cancer cells of tumor and the chemotherapy drugs released from the opened nanosphere for distributing among tissue to kill the cancer cells of the tumor.

Preparation method of radiation sensitive copolymer carrier for coating radiated nanoparticles and chemotherapy drugs

A radiocontrast agent for tau protein is provided. The agent is selectively and strongly bound to tau protein and its tangle found in brain diseases like Alzheimer's disease (AD). The agent is especially suitable to be used in PET imaging for brain diseases. Or, the agent can be used to inhibit tau protein overexpressive and, thus, stop the proceeding of brain disease.

Compound of radiocontrast agent for tau protein

The present invention establishes a fast and simple [F-18] FLT synthesis process. Solid extraction units are used for purification to achieve an equally high and constant radiochemical yield and purity in a short period of time. By using a separation method, the impurities are reduced successfully while the total synthesis time is shortened. The radiochemical purity and the corrected radiochemical yield are both high.

Method for F-18 FLT synthesis

AF-labeled monomeric galactose derivative is provided as a tomography probe. The derivative is a positron emission tomography (PET) probe. The derivative has high affinity and good stability in animal's body. The derivative can be an alternative glucose metabolism imaging agent used in clinic examination and quantification.

18F-labeled monomeric galactose derivative used as tomography probe

A liquid and a gas is constantly filled into a target chamber of a target. Then the liquid and the gas flow around the chamber and are flown out. By doing so, the target is effectively cooled down.

Circulated cooled target

A radioisotope TI-201 is produced. The process includes electroplating, irradiating, dissolving, precipitating, ion exchanging, decaying and filtering. The TI-201 obtained is a liquid having a high purity.

Radioisotope TI-201 production process

A device to rapidly obtain a solution of Pb(lead)-201 from a solution of a solid target material of Tl(thallium)-203. The solution of Pb-201 is then processed through a degeneration and an ion exchange to obtain in Tl-201 radioisotope.

Separation device of radioisotope Tl-201

Growing community of inventors

Taoyuan County, Taiwan

Ting-Shien Duh