National Taiwan University

Taiwanj Pharmaceuticals Co., Ltd.

Ting-ni Huang

Chia-Hao Chang

Ching-jang Huang

Syaulan S Yang

Yan-Feng Jiang

Sheng Hung Liu

Chiung Wen Wang

Hao Shiuan Liu

Meng-hsien Liu

Ying-chu Shih

Yi-ping Pai

The compounds represented by Formula (I), which are peripheral alkyl and alkenyl chains extended benzene derivatives, are useful as dual autotaxin (ATX)/histone deacetylase (HD AC) inhibitors. These compounds may be included in a pharmaceutical composition along with a pharmaceutically acceptable carrier, and be used in a therapeutically effective amount for prophylaxis or treatment of various diseases and disorders.

Peripheral alkyl and alkenyl chains extended benzene derivatives and pharmaceutical composition including the same

The present invention provides a method for enhancing the secretion of GLP-1 of the intestinal endocrine L-cells using a bitter compound, wherein the bitter compound is a cucurbitane-triterpenoid or allyl isothiocyanate. The bitter compound can regulate the secretion of GLP-1, thus is potentially reliable for the development of medicament or healthy victual.

Method for enhancing the secretion of GLP-1 using bitter compounds

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Taipei, Taiwan

Ting-ni Huang