Corn Products Development, Inc.

Tina Mahatdejkul-meadows

Lishan Zhao

Darren Platt

Gale Wichmann

Aditi Khankhoje

Chantal Garcia De Gonzalo

Wenzong Li

Shaina Jackson

Michael Leavell

Provided herein are compositions and methods for improved production of steviol glycosides in a host cell. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding aUDP-glycosyltransferase 40087 or its variant UDP-glycosyltransferase. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding a UDP-glycosyltransferase sr.UGT_9252778, Bd_UGT10850, and/or Ob_UGT91B1_like. In some embodiments, the host cell further comprises one or more heterologous nucleotide sequence encoding further enzymes of a pathway capable of producing steviol glycosides in the host cell. The compositions and methods described herein provide an efficient route for the heterologous production of steviol glycosides, including but not limited to, rebaudioside D and rebaudioside M.

UDP-dependent glycosyltransferase for high efficiency production of rebaudiosides

Growing community of inventors

Milpitas, CA, United States of America

Tina Mahatdejkul-meadows