Amyris, Inc.

Tina Mahatdejkul-Meadows

Lishan Zhao

Gale Wichmann

Darren Platt

Michael Leavell

Aditi Khankhoje

Wenzong Li

Chantal Garcia De Gonzalo

Shaina Jackson

Provided herein are compositions and methods for improved production of steviol glycosides in a host cell. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding akaurene oxidase or its variant kaurene oxidase. In some embodiments, the host cell further comprises one or more heterologous nucleotide sequence encoding further enzymes of a pathway capable of producing steviol glycosides in the host cell. The compositions and methods described herein provide an efficient route for the heterologous production of steviol glycosides, including but not limited to, rebaudioside D and rebaudioside M.

kaurene oxidase for high efficiency production of rebaudiosides

Growing community of inventors

Emeryville, CA, United States of America

Tina Mahatdejkul-Meadows