Neurosearch A/s

Ataxion, Inc.

Saniona A/s

Tina Holm Johansen

Dan Peters

Palle Christophersen

Ulrik Svane Sørensen

Lene Teuber

Birgitte Langer Eriksen

Dorte Strøbæk

Karin Sandager Nielsen

Charlotte Hougaard

Thomas Varming

Claus Mathiesen

Gunnar M Olsen

Alex Haahr Gouliaev

Jorgen Scheel-Kruger

Mogens Larsen

Elsebet Østergaard Nielsen

Jørgen Scheel-Krüger

Alex Haaht Gouliaev

Elsesbet Ostergaard Nielsen

Morgens Larsen

Barbara Hartz

This invention relates to novel purinyl derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.

Purinyl derivatives and their use as potassium channel modulators

This invention relates to novel purinyl derivatives of formula Ia or Ib Wherein the symbols are as defined in the Specification and of pharmaceutically acceptable salts thereof useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels, for the preparation of a medicament for such treatment and to pharmaceutical compositions containing such compounds.

Potassium channel modulating agents of Formula Ia or Ib and enantiomers and mixtures enantiomers and N-oxides thereof, and pharmaceutically acceptable salts thereof, and their use in the preparation of pharmaceutical compositions. Also, pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels, e.g., respiratory diseases, epilepsy, convulsions, vascular spasms, coronary artery spasms, renal disorders, polycystic kidney disease, bladder spasms, urinary incontinence, bladder outflow obstruction, irritable bowel syndrome, gastrointestinal dysfunction, secretory diarrhoea, ischaemia, cerebral ischaemia, ischaemic heart disease, angina pectoris, coronary heart disease, traumatic brain injury, psychosis, schizophrenia, anxiety, depression, dementia, memory and attention deficits, Alzheimer's disease, dysmenorrhea, narcolepsy, Reynaud's disease, intermittent claudication, Sjorgren's syndrome, migraine, arrhythmia, hypertension, absence seizures, myotonic muscle dystrophia, xerostomi, diabetes type II, hyperinsulinemia, premature labor, baldness, cancer, immune suppression, or pain.

Indazolyl derivatives useful as potassium channel modulating agents

This invention relates to novel guanidine derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

Guanidine derivatives and their medical use

This invention relates to novel 2-amino-pyridine derivative useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

2-aminio-pyridine derivatives and their use as potassium channel modulators

This invention relates to novel 2-(phenylamino)benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

2-(phenylamino) benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels

This invention relates to novel 2-amino benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels

The invention provides novel compounds represented by the general formula compound represented by the formula: wherein The compounds are useful as positive modulators of the AMPA-receptor.

Compounds and their use as positive AMPA receptor modulators

This invention relates to novel benzothiazine derivatives of Formula I useful as modulators of the AMPA sensitive glutamate receptors, pharmaceutical compositions comprising such compounds and their use in therapy.

Benzothiazine derivatives, their preparation and use

The invention provides novel compounds represented by general formula (I)wherein the bond represented by the broken line may be a single, double bond or absent; and if the bond is absent, then the nitrogen is substituted with a hydrogen and R; X represents SOor C&#x2550;O of CH; Y represents &#x2014;CH(R)&#x2014;, &#x2014;N(R)&#x2014;CH&#x2014;, O; and the meaning of R, R, R, R, R, R, and Rare as defined in the application. The compounds are useful as positive modulators of the AMPA-receptor.

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Smørum, Denmark

Tina Holm Johansen