Merck + Co., Inc.

Linnaeus Therapeutics, Inc.

Chromocell Corporation

Tina Garyantes

Wayne Douglas Luke

Christopher Natale

Patrick T Mooney

Robert Zhiyong Luo

David Palling

Gary S Kath

Owen B McManus

Paul R Augustine

Olga Babich

Yanlin Wang-Fischer

Srinivasan P Venkatachalan

Randal M Bugianesi

Paul B Bennett

John P Imredy

Robert Z Luo

David J Palling

Patrick Mooney

The present disclosure provides 1) an enantiomerically purified compound SRR G-1, or a derivative thereof, including specific crystal forms, salts and co-crystals that modulates G protein-coupled estrogen receptor activity, 2) pharmaceutical and cosmetic compositions comprising an enantiomerically purified SRR G-1, or a derivative thereof, and 3) methods of treating or preventing disease states and conditions and cosmetic conditions mediated through these receptors and related methods thereof in humans and animals.

Enantiomerically purified GPER agonist for use in treating disease states and conditions

Provided herein are sodium channel modulating Compounds, in particular NaV1.7 modulating compounds of Formula I or compounds of Formula I':  In particular, provided herein are processes for the preparation of, intermediates used in the preparation of, pharmaceutical compositions comprising, and therapeutic methods comprising administering such compounds. In particular, provided herein are compounds for the treatment of pain and diabetes.

Sodium channel modulators for the treatment of pain and diabetes

Methods of identifying activators and inhibitors of voltage-gated ion channels are provided in which the methods employ electrical field stimulation of the cells in order to manipulate the open/close state transition of the voltage-gated ion channels. This allows for more convenient, more precise experimental manipulation of these transitions, and, coupled with efficient methods of detecting the result of ion flux through the channels, provides methods that are especially suitable for high throughput screening.

Electrical field stimulation of eukaryotic cells

Virtual wells for use in high throughput screening assays

Growing community of inventors

Warren, NJ, United States of America

Tina Garyantes