Biogen Idec Ma Inc.

Biogen Ma Inc.

Boehringer Ingelheim International Gmbh

Yale University

Timothy Zheng

Lieping Chen

Linda C Burkly

Aniela Jakubowski

Kyungmin Hahm

Jeffrey L Browning

John Monteith Lincecum

Steve Perrin

David A Blair

Jun Wang

Steven Perrin

Methods of treating neuronal disorders, such as mechanical neuronal traumas and neurodegenerative disorders, with TWEAK or a TWEAK receptor blocking agents are presented.

Treating neurological disorders

The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.

Methods for treating TWEAK-related conditions

Methods of treating inflammatory disorders, such as rheumatoid arthritis, by modulating TWEAK and TNF-&#x3b1; are disclosed, as are other methods.

Methods for treating inflammatory bowel disease

The present invention relates to methods of modulating angiogenesis and inhibiting tumor progression by using TWEAK receptor (Fn14) agonists. In particular, methods for inhibiting angiogenesis are disclosed.

TWEAK receptor agonists as anti-angiogenic agents

Tweak receptor agonists as anti-angiogenic agents

Growing community of inventors

Boston, MA, United States of America

Timothy Zheng