Texas Instruments Corporation

Sterling Winthrop Inc.

Nycomed Imaging As

Timothy Z Hossain

John L Toner

Bruce J Murray

David A Hilborn

Robert Christopher Baumann

Robert A Snow

Ashis Kumar Saha

Chandra R Shah

Clyde W Shearman

Richard Philion

The invention provides targeting radioactive immunoreagents comprising a metal radionuclide ion, a complexing agent having structure A-I, as defined in the specification, and an immunoreactive group covalently bonded to the complexing agent. The present invention also provides novel complexing agents having the structure A-I, as defined in the specification. The targeting radioactive immunoreagents are particularly useful in therapeutic and diagnostic imaging compositions and methods.

Pyridine complexing agents and targeting immunoreagents useful in

A compound of formula ##STR1## where the two R.sup.2 groups, taken together, represent the atoms necessary to complete a macrocyclic ring structure containing at least one heteroatom coordinating site and at least one alkylene group forming part of the ring structure; R.sup.3 represents hydrogen, alkyl, alkoxy, alkylthio, alkylamino, alkylformamido, aryl, aryloxy, heterocyclyl or a protein reactive group; and R.sup.4 represents hydrogen or a protein reactive group, provided that at least one of the R.sup.4 groups is a protein reactive group, and salts, complexes and protein conjugates thereof.

Polycyclic complexing agents

Reduced soft errors in charge-sensitive circuit elements such as volatile memory cells 200 occur by using boron-11 to the exclusion of boron-10 or essentially free of boron-10 in borosilicate glass 230, 240 deposited on the substrate 206 directly over the arrays of memory cells. Boron-10 exhibits a high likelihood of fission to release a 1.47 MeV alpha particle upon capture of a naturally occurring cosmic ray neutron. This capture occurs frequently in boron-10 because of its high neutron capture cross-section. Boron-11 does not fission.

Electronic device achieving a reduction in alpha particle emissions from

Tripyridyl macrocyclic compounds that are employed in the production of a complexing agent for use in targeting radioactive immunoreagents with the following formula are disclosed: ##STR1## wherein R.sup.1 represents hydrogen, alkyl, alkoxy, alkylthio, alkylamino, alkylformamido, aryl, aryloxy, heterocyclyl or a protein reactive group;

Tripyridyl macrocyclic compounds

Electronic device and process achieving a reduction in alpha particle

A targeting radioactive immunoreagent comprising a compound having the structure ##STR1##

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Dallas, TX, United States of America

Timothy Z Hossain