Smithkline Corporation

Timothy Yu-Wen Jen

Carl Kaiser

John R Hoover

James S Frazee

Joe R Wardell, Jr

.alpha.-Aminoalkyl-3-(1,2-dihydroxyethyl)-4-hydroxy-benzyl alcohols having .beta.-adrenergic stimulant activity, particularly as selective bronchodilators, are disclosed.

.alpha.-AMINOALKYL-3-(1,2-DIHYDROXYETHYL)-4-HYDROXY-BENZYL ALCOHOLS

Novel 7-oxocephalosporins and a process for preparing them are disclosed. These compounds are useful intermediates in the preparation of other cephalosporins which have antibacterial activity.

Cephalosporin intermediates and process therefor

7-Mandelamido-3-(1-oxidopyridylthiomethyl)-3-cephem-4-carboxylic acid and substituted derivatives which have antibacterial activity are disclosed.

Mandelamidocephalosporins with improved properties

.alpha.-Aminomethyl-5-hydroxy-2-pyridinemethanols having .beta.-adrenergic stimulant activity, particularly as selective bronchodilators, are prepared generally from a 2-pyridine-carboxaldehyde by reaction with an appropriate isocyanide, via an amide intermediate followed by reduction to an amine and finally catalytic hydrogenation to remove benzyl protective groups.

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Broomall, PA, United States of America

Timothy Yu-Wen Jen