Genmab A+s

Timothy Warren Paul

Gregory Allan Sacha

Kelly Ann Roby

Jesper Valbjørn

Xiaona Jing

Nathan Alan Pease

Bodil Willumsen

Lene Schantz Harlow

Andrew Hagarman

Cale Halbleib

Brendan M Mayhugh

Disclosed herein are surfactant free antibody and antibody-drug-conjugate (ADC) formulations for anti-AXL antibodies and ADCs, including aqueous formulations, lyophilized formulations, and reconstituted formulations, as well as related processes and uses. The formulations are particularly suitable for an anti-AXL ADC based on an auristatin or DM1 derivative or other similarly hydrophobic drugs. Some formulations comprise histidine and mannitol.

Formulation for antibody and drug conjugate thereof

Disclosed herein are surfactant free lyophilized formulations of antibody-drug conjugates (ADCs), such as anti-tissue factor ADCs, and reconstituted formulations, processes and uses thereof. The formulations are particularly suitable for an anti-TF ADC based on an auristatin derivative or other similarly hydrophobic drug. Typically, the excipients of the formulations comprise or consist of histidine, sucrose, trehalose, mannitol and glycine.

Lyophilized anti-tissue factor antibody-drug conjugates

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Bloomington, IN, United States of America

Timothy Warren Paul