Pantheryx, Inc.

Ddx, Inc.

Accelr8 Technology Corporation

Bioplx, Inc.

Timothy W Starzl

H John Hanlin

MaryBeth Robinson

David W Nunnery

Mark Grabowsky

Ravi S V Starzl

Loretta M Zapp

Raymond J Playford

Richard T Mihran

Paul Kelly

Naheed Choudhry

Marguerita Cattell

Todd D Turner

Tania Marchbank

Effective and economical compositions and methods are disclosed for the treatment, and prevention of diseases and disorders associated with inflammation and/or damage to the gastrointestinal tract, including environmental enteric dysfunction. Compositions are provided comprising a synergistic combination of colostrum, immune egg, and optionally one or more additional active agents.

Compositions for management of disorders of the gastrointestinal tract

Methods and compositions are provided for durably influencing microbiological ecosystems (microbiomes) in a subject in order to prevent infection and reduce recurrence of infection by microorganisms. In some embodiments, compositions and methods are provided for the creation and use of molecularly-modified bacterial strains with the potential to prevent a variety of microorganism infections.

Methods and compositions to prevent microbial infection

The disclosure provides improved compositions and methods for passive immunization. In embodiments, a composition comprising a synergistic combination of specific polyclonal antibodies in a carrier matrix is provided. The disclosure provides effective, economical compositions and methods for the treatment of diarrhea and enteric infections in broad-spectrum, undifferentiated, or mixed clinical applications.

Compositions and methods for treatment in broad-spectrum, undifferentiated or mixed clinical applications

A system for detecting a specific substance or analyte of interest is provided that includes one or more sensing units and an instrument for analyzing the sensing units. Each sensing unit preferably includes a substrate, an attachment layer and at least one capture layer that includes a ligand layer. In one embodiment, the attachment layer is tripartite and includes a lower binding surface held to the substrate and an upper binding surface that holds the ligand layer, together with an insulating layer disposed between these two surfaces. The lower binding surface provides a durable and stable attachment to the substrate. The upper binding surface holds the ligand layer and does not jeopardize the integrity or viability thereof. The insulating layer prevents any unwanted interaction between the lower and upper binding surfaces. Each sensing unit is supported on a test piece received by the instrument. The instrument controllably positions the test piece using marks and/or codes on the test piece. The instrument measures a difference in mass in the sensing unit in connection with determining whether or not the analyte of interest is present. A light beam is used in making this measurement. In one embodiment, multiple reflections of the light beam on the same sensing unit are utilized to improve the sensitivity of the instrument. Mass enhancement techniques are also preferably utilized to effectively amplify the detected signal that is indicative of the analyte's presence. The system can also include a device for heating, humidifying and mixing materials of the sensing units, as well as preventing cross-contamination of the sensing units.

Method for specific substance and molecule detection

Sensing system for specific substance and molecule detection

A system is disclosed for making determinations related to the heat cycle in a cow. The system includes an electronic patch attached to the cow. A transmitter module for transmitting heat mount data is contained in a pouch of the electronic patch. A removable and disposable battery is also contained in the pouch for powering the transmitter module. The heat mount data from the transmitter module is sent to a repeater module to maintain the quality of the transmitted heat mount data signal. The heat mount data is re-transmitted by the repeater module to a central receiver module which includes a memory for storing heat mount data. The heat mount data is downloaded to a computer upon request using software that is also used to analyze the heat mount data. Analysis of the heat mount data results in determining a value that is useful in deciding on the optimal time to breed the cow.

Heat detection for animals including cows

Growing community of inventors

Boulder, CO, United States of America

Timothy W Starzl