Bioprotonics, Inc.

Dow Global Technolgoies LLC

Societe Des Produits Nestle S.a.

Other

Acuitas Medical Limited

Tes Technology, Inc.

Conopco, Inc.

M2m Imaging Corporation

Novartis Consumer Healthcare, Sa

Osteotronix Medical Pte Limited

Terrascend, Corp.

Panadea Medical Laboratories

Timothy W James

Jill M Martin

Haley A Lowry

Kristin James

Smeeta Khetarpaul

David R Chase

Emmanuel Lainé

Lance W Farr

Johannes Zimmer

Tyler Maiman

Nicolas Dabrowski

Wallace Y Kunimoto

Erzhen Gao

Jon T DeVries

Pablo Ignacio Groglopo Favetto

David Wyman

Andrius Dapkus

Matthew Gorman

Laetitia Allexant

Jonathan N Stearn

Christopher House

C Richard Hullihen, Iii

Ian David Parker

Freeman H Rose, Jr

Wayne Douglas Cornelius

James Rafferty

Arnold L Adams

Tara DiPippa

NIcolas Dabrowski

A method for measuring soft tissue texture to identify diseased as opposed to normal tissue by identifying textural markers that distinguish diseased tissue from normal tissue and selecting a MRμT excitation sequence and associated parameters to reveal those markers. Data is then acquired in an MR scanner responsive to the selected MRμT excitation sequence to establish a multipoint time series data set. The acquired data is then analyzed for presence of the markers.

Magnetic-resonance-based method for measuring microscopic histologic soft tissue textures

The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and/or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of signal at selected values in k-space, with multiple successive acquisitions at individual k-values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only signal values at select places in k-space, along selected directions, enables much higher in vivo resolution than is obtainable with current MRI techniques.

Selective sampling for assessing structural spatial frequencies with specific contrast mechanisms

A method for selective sampling to assess texture of a specimen using magnetic resonance (MR) excites the specimen and refocuses to provide a sample rod within the specimen. An encoding gradient pulse is applied to induce phase wrap creating a spatial encode for a specific k-value and orientation. A low non-zero magnitude gradient is then applied acting as a time dependent phase encode to produce a time varying trajectory through 3D k-space of k-value encodes while simultaneously recording multiple sequential samples of the signal at a sequence of k-values proximate the specific k-value. The receiver bandwidth is set to delineate a length of a VOI within the rod during the data sampling. The samples are then post processed at the sequence of k values, recorded within a time span while the non-zero magnitude gradient is applied, to characterize the textural features of tissue in the VOI.

Method to measure tissue texture using NMR spectroscopy with VOI length in an analysis direction defined by receiver bandwidth

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A method for identifying the chemical species of various textural elements in a targeted region of tissue wherein a volume of interest (VOI) is selectively excited and a k-encode gradient pulse is applied to induce phase wrap to create a spatial encode for a specific k-value and orientation. The specific k-value is selected based on anticipated texture within the VOI. Multiple sequential samples of the NMR RF signal encoded with the specific k-value are recorded as signal data. The Fourier Transform of the acquired signal data is then taken, wherein for each k-encode, the signal recorded is indicative of the spatial frequency power density at that point in k-space. Each peak in the NMR spectrum is then evaluated, whereby the relative contribution to the texture of tissue in the VOI at a k-value for each chemical species is determined.

Method to measure tissue texture using NMR spectroscopy to identify the chemical species of component textural elements in a targeted region of tissue

The present invention generally concerns a one piece eyewear having concealed hinges made via 3D printing. More specifically, the invention includes a U-shaped hinge with irregular offsets that are blended parametric curves that connect a lens frame to temple bars. The hinge is most flexible at its parabolic cross section and allows the temple bars to open and close, mimicking the rotational and stress bearing properties of traditional mechanical hinges. The eyewear is sculpted in a 3D modeling program that exports digital instructions for rendering the hinges, lens frame, and temple bars as a single construct by a 3D printer. The one piece eyewear is capable of accepting prescription or non-prescription lenses. A method for making the eyewear having concealed hinges is also disclosed.

One piece eyewear with concealed hinges

Growing community of inventors

Santa Barbara, CA, United States of America

Timothy W James