New York University

Timothy W Craven

Kent Kirshenbaum

Paul Michael Levine

Richard Bonneau

Susan Logan

Amanda Kasper

Jeffrey A Schneider

Provided are peptoid-peptide macrocycles. The peptoid-peptide macrocycles may have inhibitory activity towards the Wnt signaling pathway. The Wnt signaling pathway is associated with cancer and other diseases and conditions. Such diseases include, for example, pulmonary fibrosis. Also described are methods of making the peptoid-peptide macrocycles, compositions containing the peptoid-peptide macrocycles, and methods of using the peptoid-peptide macrocycles.

Peptoid-peptide macrocycles, pharmaceutical compositions and methods of using the same

Miniature protein scaffolds and compositions thereof (e.g., vaccine formulations) and methods of using same are described herein. In a particular embodiment, the miniature protein scaffold comprises an isolated &#x3b2;-strand connected via a loop to a left-handed poly proline type-II (PPII) helix formed in the absence of proline residues.

Miniature protein scaffolds and methods for use thereof

Novel hybrid polymers are disclosed that have a structure represented by the following formula I: wherein Abiotic oligomer, Polypeptide, X, Y, and Rare as described herein. The methods to prepare the hybrid polymers via novel oxazolidinyl compounds are also described.

Hybrid polymers, pharmaceutical compositions and methods of synthesizing the same

Novel methods to prepare novel polymers are disclosed. Oxazolidinyl compounds according to formula IV: are also disclosed as intermediate compounds that can be reacted with an acid to form a polymer of formula I.

Polymers, pharmaceutical compositions and methods of synthesizing the same

Novel hybrid polymers are disclosed that have a structure represented by the following wherein Abiotic oligomer, Polypeptide, X, Y, and Rare as described herein. The methods to prepare the hybrid polymers via novel oxazolidinyl compounds are also described.

Growing community of inventors

Randolph, NJ, United States of America

Timothy W Craven