Entegris, Inc.

Orbital Biosciences, LLC

Timothy Towle

William F Bowers

Basil Yankopoulos

Yasuji Suzuki

Eric McNamara

Douglas A D Norris

A purification module is provided comprising a plurality of purification cartridges, a support for the cartridges, a manifold and a bowl. In one embodiment the support for the cartridges has two pitched partial screw threads on opposing surfaces which mate with pitched screw flights on the manifold when the partial screw threads are rotated into the screw flights. The support includes fluid passageways for directing filtered fluid from the filtration cartridges, through the support and into the manifold. In another embodiment, a purification module is provided comprising a purification cartridge, a manifold and a bowl. The purification cartridge has two pitched partial screw threads on opposing surfaces of the cartridge outlet which mate with screw flights on the manifold when the partial screw threads are rotated into the mating screw flights.

Filtration module

In one embodiment according to the invention, there is provided a filter device for liquid filtration, the filter device being in fluid communication with a plurality of liquid pathways, at least one pathway of the plurality of liquid pathways having a smallest equivalent fluid flow diameter of the plurality of liquid pathways. The device comprises a filter membrane () and a filter core () comprising at least one cross hole () in fluid communication with the filter membrane, each cross hole having an equivalent fluid flow, diameter. The sum of the equivalent fluid flow diameters of the at least one cross holes does not exceed the smallest equivalent fluid flow diameter of the plurality of liquid pathways.

System and method for liquid filtration with reduced hold-up volume

An ultrafiltration device has a ported reservoir body, and a filter membrane sealed to the body along a closed contour surrounding the port(s) to provide a large area filtered outflow path. A frusto-conical end provides hydrostatic deadstopping with little or no wicking, greatly enhancing recovery time and efficiency. Methods of using the device rapidly isolate a predetermined amount of a desired retentate in the distal portion of the tube, and are also useful for quantitative transfer of smaller molecules and for multi-step processing of sample arrays Linear array strips of such chambers may be formed by bonding together mating halves with filter areas over the chamber ports. The vessel may include a rib to guide and orient filter during assembly, and/or a ledge or recess to engage and align the filter, assuring that the filter is precisely positioned and does not wander during manufacture and bonding. The vessels have a high filter area to volume ratio, maintain open filter surfaces and high rates of filtration throughout the spin, and are fully compatible with robotic loading, multistage operation and in situ multiwell plate filtrate and/or retentate assay or transfer. Attachment of the filter may be effected by heat welding. Preferably the vessel and filter are positioned between a press member and a heat sink and a superheated tool contacts the press member to selectively deliver a defined bolus of heat to the weld areas.

Ultrafiltration device and method of forming same

An ultrafiltration device has a filter membrane sealed inside a reservoir body that has one or more ports and a closed portion distal to the port(s), and the filter membrane is sealed to the body along a closed contour widely surrounding the port(s) to provide a large area filtered outflow path. The method is effective to rapidly isolate a predetermined amount of a desired retentate in the distal portion and is also useful for quantitative transfer of smaller molecules and for multi-step processing of sample arrays. A frusto-conical peripheral filter provides high ratio of effective filter area, and may be configured for hydrostatic deadstopping and little or no wicking, greatly enhancing recovery time and efficiency. Novel constructions and methods of manufacture enhance filtration or separation vessels of various sizes.

Growing community of inventors

Lee, NH, United States of America

Timothy Towle