Octane Biotech Inc.

Lonza Walkersville, Inc.

Lonza Cologne Gmbh

Timothy Smith

Nuala Trainor

Yaling Shi

Eytan Abraham

Kelly Purpura

Timo Gleissner

Erika McAfee

Joseph O'Connor

Guy Oram

Samatha Bandapalle

Taylor Plant

Ian Grant

Ann Siehoff

Chase McRobie

Raelyn Daniels

Matthew Hewitt

Kevin Middleton

Alexis Pietak

Systems, devices and methods for automatic magnetic separation of magnetized targets in a biological sample are herein disclosed, where they comprise a magnetic field shield/barrier controllably operable to control the magnetic field in terms of reaching and attracting the magnetized targets within the biological sample.

Magnetic separation

An automated carousel and system configured for translationally moving a plurality of biological production units in unison along a vertical frame while maintaining a precise alignment of each of the biological production units relative to gravity, and simultaneously providing independent dynamic adjustment of the axial orientation of each of the plurality of biological production units relative to gravity. The automated carousel may be adapted for use with a variety of biological production units supporting cell culture and/or tissue engineering systems in various clinical and laboratory settings and provides for ergonomic use thereof.

Carousel for modular biologic production units

The present disclosure provides cell culture chambers for use in automated cell engineering systems, and in particular, cell culture chambers that include improved cell-contacting surfaces. Improved cell-contacting surfaces can include a surface coating that promotes cell growth, adherence, differentiation, maintenance of phenotype, and/or improves transduction; a cell-contacting surface comprising a non-porous, gas-permeable material; as well as other modifications to the cell-contacting surfaces. Cassettes comprising the cell culture chambers are also provided.

Cell culture chamber with improved cell-contacting surfaces

An automated cell culture and tissue engineering system comprising defined and separate environmental zones provide for increased control and maintenance of the internal environment of the system such that the temperature, air flow and gases surrounding the bioreactor module form one zone that is maintained separately to a second zone formed surrounding the reagent fluid reservoir. The system further comprises means for elimination and/or management of condensation within the second zone of the system.

Cell culture and tissue engineering systems with controlled environmental zones

The present disclosure provides an automated method of producing genetically modified immune cells, including chimeric antigen receptor T (CAR T) cells, utilizing a fully-enclosed cell engineering system.

End-to-end cell therapy automation

Growing community of inventors

Kingston, Canada

Timothy Smith