Array Biopharma Inc.

Celgene Corporation

Intermune, Inc.

Timothy S Kercher

Steven Wade Andrews

Yutong Jiang

Shelley Allen

Julia Haas

Kevin Ronald Condroski

Lily Huang

Joshua Hansen

Matthew Daniel Correa

Mark A Nagy

James F Blake

Gabrielle R Kolakowski

Barbara J Brandhuber

Jeongbeob Seo

Shannon L Winski

Brandon Wade Whitefield

Matthew David Alexander

Antonia Lopez-Girona

Rama Krishna Narla

Veronique Plantevin-Krenitsky

Virginia Heather Sharron Grant

John J Sapienza

Scott D Seiwert

Shuichan Xu

Patrick Papa

Lawrence M Blatt

Stephen Norris

Sogole Bahmanyar

Evan J Horn

Christopher Mayne

April L Kennedy

Massimo Ammirante

Surendra Nayak

Hon-Wah Man

Bin Wang

Brian Edwin Cathers

Nanfei Zou

Michael Lyon

Daniel W Pierce

Lilly L Wong

Paula Alessandra Tavares-Greco

Xiaoling Lu

Courtney G Havens

Robert J Kaus

Gerald D Artman, Iii

Joseph R Piccotti

James Carmichael

Leonid Beigelman

Pierre Martin

Dehua Huang

Weidong Liu

Paul Nichols

Allen A Thomas

Andreas Schumacher

C Todd Eary

Tarek Sammakia

Soraya Carrancio

Bradley Barnett

Qian Zhao

Brad Owen Buckman

Laurence Edward Burgess

Ellen Ruth Laird

Mark Laurence Boys

Robert D Groneberg

Roy Leonard Harris, Iii

Darren Martin Harvey

Roy L Harris, Iii

Virginia H Grant

Christopher F Kraser

Eugene Tarlton

Gordon L Bray

Paula A Tavares-greco

Veronique Plantevin-krenitsky

Soraya Carranclo

Bradley R Barnett

Sogoie Bahmanyar

Shuichan Su

Gerald D Iii Artman

Stephen S Andrews

Steven S Andrews

Provided herein are piperidine dione compounds having the following structure:

Substituted 3-((3-aminophenyl)amino)piperidine-2,6-dione compounds, compositions thereof, and methods of treatment therewith

Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

Antiproliferative compounds and methods of use thereof

Provided herein are 4-aminoisoindoline-1,3-dione compounds having the following structure:

Substituted 4-aminoisoindoline-1,3-dione compounds, compositions thereof, and methods of treatment therewith

Provided herein are 4-aminoisoindoline-1,3-dione compounds having the following structure: 

Provided herein are piperidine dione compounds having the following structure: 

Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.

Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain

Compounds useful for the treatment of pain or cancer in a mammal.

Methods of treatment using pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds

Compounds of Formula I: and salts thereof in which R, R, R, R, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.

Substituted pyrazolo[l,5-a]pyrimidine compounds as Trk kinase inhibitors

Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome. 

Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R, R, R, R, R, R, X, Y, B, and Ring C are as defined herein, and wherein the Y&#x2014;B moiety and the NH&#x2014;C(&#x2550;X)&#x2014;NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.

Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as TrkA kinase inhibitors

Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors

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San Diego, CA, United States of America

Timothy S Kercher