Lawrence Livermore National Security, LLC

University of California

Timothy S Carpenter

Mimi Cho Yung

Carlos A Valdez

Matthew A Coleman

Feliza A Bourguet

David Frank Savage

Heather Ann Enright

Nicholas A Be

Tuan H Nguyen

Brian J Bennion

Saphon Hok

Hio Leong Lao

Michael A Malfatti

Tek Hyung Lee

Described herein are oxime compounds capable of inactivating OP-based AChE inhibitors, crossing the blood brain barrier (BBB), and/or reactivation of OP-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more OP-based AChE inhibitors, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of OP-based AChE inhibitors for decontamination.

Compounds for central reactivation of organophosphorus-based compound-inhibited acetylcholinesterase and/or inactivation of organophosphorus-based acetylcholinesterase inhibitors and related compositions methods and systems for making and using them

Engineered microcompartment proteins, and related engineered microcompartment, vectors, cells compositions, methods and systems configured to provide within a cell one or more proteins non-native to the cell are described, wherein the one or more proteins non-native to the cell are contained in at least one engineered microcompartment within the cell.

Engineered microcompartment protein and related methods and systems of engineering bacterial systems for non-native protein expression and purification

The invention described herein relates to methods, systems, compositions and cells to provide one or more toxic non-native proteins in a cell, wherein the one or more toxic non-native proteins are contained in at least one empty microcompartment within the cell.

Methods and systems for engineering bacterial systems to shield toxicity during non-native protein expression and purification

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Livermore, CA, United States of America

Timothy S Carpenter