Adamas Pharmaceuticals, Inc.

Novartis Vaccines & Diagnostics, Gmbh

Adamas Pharmaceutical, Inc.

Timothy S Burkoth

Timothy J Fultz

Gregory T Went

Laurence R Meyerson

Seth Porter

Ronald N Zuckermann

Christoph Reinhard

Anne B Jefferson

Disclosed are compositions comprising amantadine, or a pharmaceutically acceptable salt thereof, and one or more excipients, wherein at least one of the excipients modifies release of amantadine. Methods of administering the same are also provided.

Composition and method for treating neurological disease

A method of administering amantadine is provided. The method comprises orally administering to a subject a pharmaceutical composition comprising amantadine, or a pharmaceutically acceptable salt thereof, and one or more excipients, wherein at least one of the excipients modifies release of the amantadine. A dose of the composition provides a mean change in amantadine plasma concentration as a function of time (dC/dT) that is less than 40% of the change in amantadine plasma concentration provided by a dose of the same quantity of an immediate release form of amantadine. The change in plasma concentration over time (dC/dT) is measured in a single dose human pharmacokinetic study in a defined time period of 0 to 4 hours after administration. The amantadine, or pharmaceutically acceptable salt thereof, is administered once daily at a dose of 300 to 500 mg per day.

Compositions incorporating small interfering ribonucleic acid (siRNA) and certain lipid-conjugated polyamide compound-based delivery vehicles that are particularly useful in the delivery siRNA and other polynucleotides to cells. Also, methods of making and using the compositions.

Cell transfecting formulations of small interfering RNA related compositions and methods of making and use

The invention provides methods and compositions for administering an NMDA receptor antagonist (e.g., memantine) to a subject.

Method and composition for administering an NMDA receptor antagonist to a subject

The invention provides methods and compositions for treating or preventing neurological disorders.

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Lake Bluff, IL, United States of America

Timothy S Burkoth