Algipharma As

University College Cardiff Consultants Limited

Timothy Rutland Walsh

David Thomas

Arne Dessen

Rolf Myrvold

Edvar Onsoyen

Elaine Ferguson

Edvar Onsøyen

Edvar Onsoeyen

The invention provides a method of overcoming resistance to at least one antibiotic in a multidrug resistant bacterium, said method comprising contacting said bacterium with an alginate oligomer together with the antibiotic. The multidrug resistant bacterium may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides an alginate oligomer for use together with at least one antibiotic in treating a subject infected, suspected to be infected, or at risk of infection, with a multidrug resistant bacterium to overcome resistance to the antibiotic in said multidrug resistant bacterium. In another aspect the method can be used to combat contamination of a site with multidrug resistant bacteria, e.g. for disinfection and cleaning purposes.

Alginate oligomers for use in overcoming multidrug resistance in bacteria

The invention concerns a novel antimicrobial peptide (AMP) polymer conjugate comprising at least one AMP, typically colistin, and a dextrin polymer wherein said dextrin polymer has a molecular weight between 5,000-60,000 g/mol and is modified by the additions of pendant groups which increase the stability of the conjugate and so delays its degradation thereby slowing the rate at which the AMP is released.

Therapeutic conjugates

The invention provides a method to improve the efficacy of an antibiotic to inhibit the growth of, said method comprising using said antibiotic together with an alginate oligomer. Themay be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides an alginate oligomer for use together with at least one antibiotic in treating a subject infected, suspected to be infected, or at risk of infection, with. In another aspect the method can be used to combatcontamination of a site e.g., for disinfection and cleaning purposes.

Treatment of Acinetobacter with alginate oligomers and antibiotics

Growing community of inventors

Cardiff, United Kingdom

Timothy Rutland Walsh