Revagenix, Inc.

Timothy Robert Kane

Michael J Lopez

Frederick Cohen

Andrew Calabrese

Nikolai Evdokimov

Malken Bayrakdarian

Darin Hildebrandt

Samuel Desjardins

Olivier Soueidan

Ryan Cirz

Logan Andrews

Sanjia Xu

John Knox

Sanijia Xu

The present disclosure relates to novel methods for preparing antibacterial aminoglycoside compounds and the compounds used in such preparations.

Modular synthesis of aminoglycosides

Provided herein are aminoglycoside compounds, such as compounds of formula (I), (II), (III), (IV), (IVa), (V), (VI), (VIIa), or (VIIb) or pharmaceutically acceptable salts, solvates, stereoisomers, or tautomers of any of the foregoing, useful as therapeutic or prophylactic agents. Also provided herein are methods for their preparation. The compounds may be useful in treating a bacterial infection in a subject, for example a Gram-negative bacterial infection.

Aminoglycosides and uses thereof

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San Mateo, CA, United States of America

Timothy Robert Kane