California Institute of Technology

Emory University

Axial Therapeutics, Inc.

Axial Biotherapeutics, Inc.

Timothy R Sampson

Sarkis K Mazmanian

Anthony Stewart Campbell

Arash Grakoui

David S Weiss

Aryn Alaine Price

Disclosed herein are methods and compositions that can be used to improve motor deficits and neuroinflammation in subjects in need, for example subjects suffering from neurodegenerative disorders (e.g., Parkinson's disease). Also disclosed are methods and compositions that can be used to diagnose neurodegenerative disorders, such as Parkinson's disease.

Regulate gut microbiota to treat neurodegenerative disorders

The present disclosure provides methods and compositions for the prevention, amelioration, or alleviation of one or more neurological disorders associated with microbially-induced amyloid formation. Methods of inhibiting, ameliorating, reducing the likelihood, delaying the onset of, treating, or preventing an amyloid disorder are disclosed. Methods of identifying compounds capable of inhibiting the formation of microbially-induced amyloid fibrils are disclosed.

Inhibitors of microbially induced amyloid

This disclosure relates to Cas9-nucleic acid complexes and uses related thereto. In certain embodiments, the disclosure contemplates transgenic plants and animals genetically engineered to express Cas9-nucleic acid complexes disclosed herein. In certain embodiments, the disclosure relates to methods of treating or preventing, diseases, conditions, cancer, viral infections or other pathogenic infection using vectors configured to express a Cas9-nucleic acid complex disclosed herein.

CAS9-nucleic acid complexes and uses related thereto

Cas9-nucleic acid complexes and uses related thereto

Growing community of inventors

Los Angeles, CA, United States of America

Timothy R Sampson