Radiant Medical, Inc.

Mvrx, Inc.

Zoll Circulation, Incorporated

Heartport, Inc.

Medtronic Vascular, Inc.

Advanced Cardiovascular Systems, Inc.

Transvascular, Inc.

Sage Products, Inc.

Pneumrx, Inc.

Ample Medical, Inc.

Other

Niveus Medical, Inc.

Stanford Surgical Technologies, Inc.

Zell Circulation, Inc.

Timothy R Machold

Robert T Chang

David A Rahdert

Wade A Keller

Alex T Roth

Joshua Makower

J Christopher Flaherty

Philip Christopher Evard

Jason Brian Whitt

Michael W Dae

John A Macoviak

Wesley D Sterman

John Henry Stevens

John T Garibotto

Nicole Denise Bloom

Lawrence C Siegel

Patrick Edward Macaulay

David R Tholfsen

Patricia E Curtis

Jose Alejandro

David Jerry Scott

Edward A Oliver

Dave J Scott

Michael T Dineen

Margaret W Tumas

Rick A Soss

Hanson S Gifford, Iii

Zachary John Malchano

Curtis Peter Tom

Marc Jensen

Brian J Fahey

Charles S Taylor

Russell J Redmond

Claude A Vidal

Robert S Ginsburg

Thomas Banks

Alan Robert Selfridge

Michi E Garrison

Mark L Mathis

Theodore Charles Lamson

William S Peters

Arlene S Ginsburg, Legal Representative

Ganesh Manoharan

Mark A Saab

Brian S Donlon

Paul M Stull

Jaime Vasquez

Andrew Stein

Wade E Keller

Bojana Spahic

Ed Oliver

Jason Rogers

John W Gaiser

Craig E Mar

Motasim Mahmoud Sirhan

Janine C Robinson

Jeffrey P Callister

Jeffry J Grainger

Richard L Mueller, Jr

Hilary J Hampton

Verna Rodriguez

Mary B Michaels

Robert Ginsburg, Incapacited

Scott Kaarto

Robert Ginsburg, Legally Incapacitated

John P Shanahan

Patrick Edward Macauley

Delivery systems, methods and associated devices for management of an elongate element having sections with differing mechanical properties, in particular, for management of a loop of suture-wire element extending proximally from a delivery catheter for deployment of a heart implant. Such management devices can include an inner feature (e.g. outward facing groove or series of tabs) along an inner circle about which a suture can be coiled and an outer feature (e.g. inward facing groove or tabs) to engage and constrain a wire section having increased stiffness within a coil having a larger diameter than the coiled suture. Such devices can be provided separately or can be integrated within a handle of the delivery catheter. Methods of loading suture-wire management devices and utilizing such devices during deployment of an implantable anchor are also described herein.

Suture management device and methods

A method of reducing interference with an electrical monitoring device includes sensing an interference signal at a first location in a body resulting from reception of a second signal at a second location in the body, and delivering an electrical counter signal to the patient that destructively interferes with the interference signal to prevent interference with the electrical monitoring device.

Systems and methods to reduce sensor interference associated with electrical therapies

Delivery systems, methods and associated devices to facilitate delivery and deployment of a heart implant. Such delivery systems and methods of delivery include use of a pair of magnetic catheters, including an anchor delivery catheter carrying an anchor, which can be stacked with or can be axially offset from the magnetic head. Such systems further include use of a puncturing guidewire advanceable through the magnetic head of the anchor delivery catheter to establish access to a chamber of a heart and which is attached to a bridging element such that continued advancement of the guidewire draws a bridging element attached to the first anchor across the chamber of the heart while the bridging element remains covered by the magnetically coupled catheters. Methods and devices herein also allow for cutting and removal of a bridge element of a deployed heart implant.

Delivery system and methods for reshaping a heart valve annulus, including the use of magnetic tools

Anchors for securing an implant within a body organ and/or reshaping a body organ are provided herein. Anchors are configured for deployment in a body lumen or vasculature of the patient that are curved or conformable to accommodate anatomy of the patient. Such anchors can include deformable or collapsible structures upon tensioning of a bridging element in a lateral direction, or segmented tubes that can be adjusted by tightening of one or more tethers extending therethrough. Such anchors can be used as a posterior anchor in a blood vessel in implant systems having a tensioned bridging element extending between the posterior anchor and an anterior anchor deployed at another location within or along the body organ. Methods of deploying such anchors and use of multiple anchors or multiple bridging elements to a single anchor are also provided.

Devices, systems and methods for reshaping a heart valve annulus

A method of reducing stimulation signal interference with an electrical monitoring device includes sensing an electrical interference signal at a first location in a body resulting from delivery of an electrical muscle stimulation signal at a second location in the body, and delivering an electrical counter signal to the patient that destructively interferes with the electrical interference signal to prevent interference with the electrical monitoring device.

Implants or systems of implants and methods apply a selected force vector or a selected combination of force vectors within or across the right atrium, which allow tricuspid valve leaflets to better coapt. The implants or systems of implants and methods make possible rapid deployment, facile endovascular delivery, and full intra-atrial retrievability. The implants or systems of implants and methods also make use of strong fluoroscopic landmarks. The implants or systems of implants and methods make use of an adjustable implant. The implants or systems of implants and methods may utilize a bridge stop to secure the implant.

Devices, systems, and methods for reshaping a heart valve annulus

Methods and systems for reducing interference in a therapeutic energy delivery system by delivering an electrical therapeutic signal to a patient to provide a therapeutic benefit to the patient, and delivering an electrical counter signal to the patient that destructively interferes with an electrical interference signal resulting from delivering the electrical therapeutic signal.

Anchors for securing an implant within a body organ and/or reshaping a body organ are provided herein. Anchors are configured for deployment in a body lumen or vasculature of the patient that are curved or conformable to accommodate anatomy of the patient. Such anchors can include deformable or collapsible structures upon tensioning of a bridging element in a lateral direction, or segmented tubes that can be adjusted by tightening of one or more tethers extending therethrough. Such anchors can be used as a posterior anchor in a blood vessel in implant systems having a tensioned bridging element extending between the posterior anchor and an anterior anchor deployed at another location within or along the body organ. Methods of deploying such anchors, and use of multiple anchors or multiple bridging elements to a single anchor are also provided.

Guidewires suitable for use in a system for implanting a lung volume reduction device are disclosed. The guidewire includes an outer sheath having proximal and distal ends, and comprising a proximal section, a transition section, and a distal section. The proximal section extends from the proximal end of the sheath to the transition section, and the distal section extends from the transition section to the distal end of the sheath. The distal section defines a bore extending from the transition section to the distal end of the sheath and an inner core having proximal and distal ends. The inner core extends through the bore of the distal section of the sheath, wherein the inner core is fixed to the sheath at the transition section, and wherein the distal end of the inner core is fixed to the distal end of the sheath at the distal end of the sheath.

Guidewire

Implants or systems of implants and methods apply a selected force vector or a selected combination of force vectors within or across the left atrium, which allow mitral valve leaflets to better coapt. The implants or systems of implants and methods make possible rapid deployment, facile endovascular delivery, and full intra-atrial retrievability. The implants or systems of implants and methods also make use of strong fluoroscopic landmarks. The implants or systems of implants and methods make use of an adjustable implant and a fixed length implant. The implants or systems of implants and methods may also utilize a bridge stop to secure the implant, and the methods of implantation employ various tools.

Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools

A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient=s vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36 degrees C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient=s shivering threshold (typically approximately 35.5 degrees C.). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient=s body to normothermia or near normothermia.

Inhibition of platelet activation, aggregation and/or adhesion by hypothermia

Implants or systems of implants and methods apply a selected force vector or a selected combination of force vectors within or across the left atrium, which allow mitral valve leaflets to better coapt. The implants or systems of implants and methods make possible rapid deployment, facile endovascular delivery, and full intra-atrial adjustability and retrievability years after implant. The implants or systems of implants and methods also make use of strong fluoroscopic landmarks. The implants or systems of implants and methods make use of an adjustable implant and a fixed length implant. The implants or systems of implants and methods may also utilize an adjustable bridge stop to secure the implant, and the methods of implantation employ various tools.

Devices, systems, and methods for reshaping a heart valve anulus, including the use of a bridge implant having an adjustable bridge stop

Growing community of inventors

Moss Beach, CA, United States of America

Timothy R Machold