Bayer Healthcare LLC

Leland Stanford Junior University

The United States Government As Represented by the Department of Veterans Affairs

Timothy Myles

Terry Hermiston

Uwe Gritzan

Michael Strerath

Frank Dittmer

Ye Jin

John E Murphy

Lawrence L K Leung

Michael J Morser

Therapeutic antibodies specific for osteopontin and methods of using them for treating osteopontin-associated disorders are provided. In particular, antibodies, or antigen-binding fragments thereof, that inhibit thrombin-cleavage of osteopontin or block the activity of thrombin cleavage fragments of osteopontin are provided. Additionally, antibody conjugates and pharmaceutical compositions or formulations comprising the antibodies or antibody conjugates as well as kits including the antibodies, conjugates, or formulations are also provided.

Therapeutic antibodies against osteopontin

This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin &#x3b2; complexed with heparin and/or heparin-like structure (AT&#x3b2;H). These AT&#x3b2;H binding proteins can block the anti-coagulant activity of AT&#x3b2; to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies.

Monoclonal antibodies against antithrombin beta

Monoclonal antibodies against antithrombin &#x3b2;

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Sunnyvale, CA, United States of America

Timothy Myles