The University of Texas System

Moleculin, LLC

Timothy Madden

Izabela Fokt

Slawomir Szymanski

Waldemar Priebe

Jeffrey Myers

Charles Conrad

Charles A Conrad

Stanislaw Skora

Marcin Cybulski

Arkadiusz Kazimierski

Jeffrey N Myers

Waldeman Priebe

Liwei Guo

Leposava Antonovic

Charles (deceased) Conrad

Stainslaw Skora

Compounds and methods of using the same to inhibit glycolysis and treat cancer and other diseases are disclosed.

Esters of 2-deoxy-monosaccharides with anti proliferative activity

Provided herein are compounds which intercalate into the DNA of a cell and are capable of crossing the blood brain barrier of a formula provided herein. Pharmaceutical compositions of the compounds and methods of treating cancer, for example brain, lung, or pancreatic cancer, are also provided herein.

DNA binding agents with a minor groove binding tail

Esters of 2-deoxy-monosacharides with anti proliferative activity

Provided herein are methods of treating brain tumors by administering a therapeutically effective amount of a compound of the Formulas I or II to a patient in need thereof.

Inhibitors of glycolysis useful in the treatment of brain tumors

Pyridine compounds effective in modulation STAT3 and/or STAT5 activation are provided that are useful in the prevention and treatment of proliferative disease and conditions including cancer, inflammation and proliferative skin disorders.

Inhibitors of proliferation and activation of signal transducer and activator of transcription (STATs)

Novel compounds and methods of using the same to inhibit glycolysis and treat cancer and other diseases are provided herein.

Acetates of 2-deoxy monosaccharides with anticancer activity

The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as inhibitors of Jak2/STAT3 pathways and downstream targets and inhibit the growth and survival of cancerous cell lines.

Orally bioavailable caffeic acid related anticancer drugs

Inhibitors of proliferation and activation of signal transducer and activators of transcription (STATS)

Embodiments of the invention generally relate to pharmaceutical compositions containing at least one caffeic acid compound and methods for the topical treatment of proliferative and inflammatory skin disorders such as plaque psoriasis, atopic dermatitis, and other disorders. In some embodiments, the topical treatment includes applications of the pharmaceutical composition containing at least one caffeic acid compound or a mixture of caffeic acid compounds such as caffeic acid ester compounds, caffeic acid amide compounds, analogues thereof, derivatives thereof, salts thereof, or mixtures thereof. The pharmaceutical composition or topical dosage may contain the caffeic acid compound at a concentration by weight within a range from about 0.01% to about 20%, preferably, from about 0.1% to about 15%, preferably, from about 1% to about 10%, more preferably, from about 3% to about 7%, and more preferably, from about 4% to about 6%.

Methods of treating skin disorders with caffeic acid analogs

Methods of treating glioblastoma and pancreatic cancer are provided by the administration of a therapeutically effective amount of a iodo-hexose compound to a subject in need thereof. The subject disclosure includes methods of treating glioblastoma and pancreatic cancer comprising the administration of a therapeutically effective amount of a 2-deoxy-2-iodo-D-hexose compound including 2-deoxy-2-iodo-D-mannose, 2-deoxy-2-iodo-D-glucose, 2-deoxy-2-iodo-D-galactose, and/or 2-deoxy-2-iodo-D-talose to a subject in need thereof.

Growing community of inventors

Sugar Land, TX, United States of America

Timothy Madden