Novartis Ag

Irm LLC

Novartis Ac

Timothy M Ramsey

Kenneth Walter Bair

Frederick Ray Kinder, Jr

Michael Lloyd Sabio

Pascal Furet

Xiaolin Li

Valentina Molteni

Giorgio Caravatti

Muneto Mogi

Werner Breitenstein

Christopher Michael Adams

Jon Christopher Loren

Juliet Nabakka

Xiaodong Liu

Donatella Chianelli

Achim Schlapbach

Patricia Imbach

Dieter Scholz

Stephen Hedrick Poor

Qin Zhang

Henry Wu

The present invention provides in one aspect methods for treating ocular diseases by administering pharmaceutical compositions comprising an inhibitor of colony stimulating factor-1 (CSF-1) receptors. In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one inhibitor of CSF-1R. The inhibitor can also be a selective inhibitor of CSF-1R in certain embodiments.

Methods for treating ocular disease using inhibitors of CSF-1R

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of c-kit, PDGFR and PDGFR kinases.

Compounds and compositions as c-kit and PDGFR kinase inhibitors

The invention relates to phenyl-[4-(3-phenyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amine derivatives and to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives&#x2014;alone or in combination with one or more other pharmaceutically active compounds&#x2014;for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumor.

Phenyl-[4-(3-phenyl-1h-pyrazol-4-yl)-pyrimidin-2-yl)-amine derivatives

The present invention relates to certain substituted polyketides of formula I, wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds in treating tumors.

Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors

The present invention relates to certain substituted polyketides of formula I, wherein A, B and C are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds in treating tumors.

The present invention relates to certain substituted polyketides of formula I,wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds in treating tumors.

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Sparta, NJ, United States of America

Timothy M Ramsey