Miles Inc.

Timothy M Coryn

Arthur L Lau

Carrie A Ritucci

David W Thompson

A test device and method of determining the presence and concentration of proteins, including albumin and Bence Jones proteins, in a test sample are disclosed. The test device includes a test pad comprising a new and improved carrier matrix incorporating an indicator reagent composition capable of interacting with proteins to produce a visually or instrumentally detectable and/or measurable response. The new and improved carrier matrix of the test pad comprises a fibrous, bibulous substrate, such as filter paper, homogeneously impregnated with a polymerized urethane-based compound dispersed in a liquid vehicle comprising an aprotic solvent and an alcohol. The resulting non-greening carrier matrix provides improved color resolution and increased sensitivity to proteins in dry phase test strip assays, thereby affording a more accurate and trustworthy protein assay of liquid test samples, such as urine. The non-greening carrier matrix also essentially eliminates indicator reagent composition runover onto adjacent test pads, such as a pH test pad, in test strips used to assay for more than one analyte. Also disclosed is a method of making the device.

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Mishawaka, IN, United States of America

Timothy M Coryn