Emory University

Children's Healthcare of Atlanta, Inc.

Eureka Therapeutics, Inc.

Timothy M Acker

Dennis C Liotta

Stephen F Traynelis

Yao Jing

Hong Liu

Yiyang Xu

Jingyi Xiang

Pengbo Zhang

Javier Morales

Yoko Nakano

This disclosure relates to pyrazoline dihydroquinolone derivatives, pharmaceutical compositions, and uses. In certain embodiments, the compounds are selective NMDA receptor inhibitors and are useful in therapeutic methods related thereto. In certain embodiments, this disclosure relates to pharmaceutical compositions comprising a compound of the following formula:

Pyrazoline dihydroquinolones, pharmaceutical compositions, and uses

The present application provides constructs comprising an antibody moiety specifically recognizing Glypican 3 (GPC3), such as a cell surface-bound GPC3. Also provided are methods of making and using these constructs.

Constructs specifically recognizing glypican 3 and uses thereof

This disclosure relates to pyrazoline dihydroquinolone derivatives, pharmaceutical compositions, and uses. In certain embodiments, the compounds are selective NMDA receptor inhibitors and are useful in therapeutic methods related thereto. In certain embodiments, this disclosure relates to pharmaceutical compositions comprising a compound of the following formula: 

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San Francisco, CA, United States of America

Timothy M Acker