Cordis Corporation

Cardinal Health Switzerland 515 Gmbh

Timothy Lash

Daniel Olsen

Adam Groothuis

Salvatore G Caldarise

Matthew E Krever

Erin Black

Rudolph Cedro, Jr

Paul D'Antonio

Ted Bachman

Natalie D Macon

Paritosh Dhawale

Paul D'antonio

Rudolph Cedro

Natalie Macon

A system and method for the treatment of mitral valve regurgitation by reshaping the mitral valve annulus using one or more plications of annular or adjacent tissue each fixed by a retainer is described. The system includes four devices to achieve such percutaneous direct plication annuloplasty. The first is a crossing catheter having a prolapseable or curved tip. Second, a deflecting guide catheter is used to provide a means for guiding the plication device into proper position at the subvalvular region of the mitral valve annulus. Third, the plication device is then used to make plications in the subvalvular region of the mitral valve annulus. Fourth, a 'C' shaped retainer with deformable ends is deployed by the plication device in order to retain the plicated tissue in the plicated form. A transseptal approach may be used to plicate and retain tissue on the atrial side of the mitral valve to achieve a reduction in mitral valve regurgitation.

Method and system for plicating tissue in a minimally invasive medical procedure for the treatment of mitral valve regurgitation

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Hillsborough, NJ, United States of America

Timothy Lash