University System of Maryland

Northern Arizona University

Arizona State University

Cantimer, Inc.

Timothy L Vail

Mark E Shirtliff

Jeffrey Leid

Rebecca A Brady

Jennifer M Kofonow

Ray F Stewart

Timothy L Porter

Jennifer A Kofonow

Jeffrey G Leid

The compositions and methods relate to an organic polymer-inorganic particle sensor material for detecting analytes. Interactions between the polymer and the particles are affected by the presence of analyte, which displaces the polymer and increases its free volume. This change in free volume can be detected, e.g., using an embedded piezoresistive microcantilever (EPM) sensor. Analytes that can be detected include noxious substances, such as hydrogen cyanide gas and carbon monoxide.

Microsensor material and methods for analyte detection

The present invention relates to a method for in vivo detection of a biofilm infection residing in a mammal, the method comprising (i) administering to the mammal a diagnostic-effective amount of a biofilm-specific probe, wherein the probe comprises a bio film-targeting moiety and a paramagnetic nanoparticle core; and (ii) imaging the mammal to detect the presence of the biofilm infection by observing the mammal using a magnetic resonance diagnostic technique after the biofilm-specific probe has been provided sufficient time to selectively bind to the bio film infection that may be present in the mammal. The invention also relates to methods of treatment of a bio film infection, and compositions and kits useful in the detection and/or treatment of bio film infections.

In vivo biofilm infection diagnosis and treatment

The present invention provides methods and kits for biofilm detection.

Methods and devices for the detection of biofilm

Growing community of inventors

Parks, AZ, United States of America

Timothy L Vail