Abbott Laboratories Corporation

Warner-lambert Company

Zoetis Services LLC

Indevus Pharmaceuticals, Inc.

Other

N.v. Organon

Zoetis LLC

Msd Oss B.v.

Sandra Marie Jennings

Timothy Lee Stuk

Timothy L Stuk

Anthony Ralph Haight

Howard E Morton

Hing L Sham

Thomas J Sowin

Michael S Allen

Daniel S Reno

Jien-Heh J Tien

M Robert Leanna

Timothy A Robbins

David Scarpetti

Linda M Lijewski

Francis A Kerdesky

Michael Gerard Pamment

Jade Douglas Nelson

Laura Melcher

Donald E Butler

Daniel W Norbeck

Chen Zhao

Denton C Langridge

Randall Lee Dejong

Richard Andrew Ewin

Paul D Johnson

Rajendran Vairagoundar

Graham M Kyne

Denis Billen

Todd M Maddux

Gerardus Johannes Kemperman

Tomasz Respondek

Jacobus Johannes Maria Van Der Linden

Mark R Cox

Valerie Ann Vaillancourt

Denis Martin Sobieray

Bradley Dean Tait

Nathan Anthony Logan Chubb

Michael P Curtis

James N Wemple

Christopher Andrew Gajda

Victor Fedij

Brian Keith Huckabee

Sanjay Menon

Kenneth Thomas Porter

Jerome A Menzia

Brian Stuart Moon

Sean David William Greenwood

Sean D W Greenwood

Vageesha Warnajith Liyana Gunawardana

Valerie Sue Westrick

Michael Curtis

Sean Dw Greenwood

Defined herein are immunomodulating Formula (1) compounds wherein R, R, R, R,

Immunomodulating urea azalides

Defined herein are immunomodulating Formula (1) compounds wherein R, R, R, R, Rand W are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, and a pharmaceutically acceptable salt thereof; or use of said compound of Formula (1) to prepare a medicament for treating an inflammatory and/or immunological disease or disorder in an animal.

Described herein are improved processes for the preparation of the 7H-pyrrolo[2,3-d]pyrimidine compound, N-methyl-1-{trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}-methanesulfonamide, intermediates thereof, and veterinary acceptable salts thereof.

Process for preparing 7H-pyrrolo[2,3-D]pyrimidine compounds

The invention recites an improved process for preparing spirocyclic isoxazoline derivatives of Formula (1) wherein '*', R, R, and Rare as described herein. 

Synthesis of spirocyclic isoxazoline derivatives

The invention recites spirocyclic isoxazoline derivatives of Formula (V.1), Formula (V.2), Formula (V.1.1), and Formula (1) stereoisomers thereof, veterinarily acceptable salts thereof, compositions thereof, processes for making, and their use as a parasiticide in an animal. The variables A, V, Z, W, W, W, W, Y, X, R, R, R, R, R, R, n, and '' are as described herein.

Spirocyclic isoxazoline derivatives as antiparasitic agents

The invention relates to a novel process for the preparation of asenapine, i.e. trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, as well as to novel intermediate products for use in said process.

Process for the preparation of asenapine and intermediate products used in said process

An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.

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The present invention relates to methods for making racemic 2-(7-chloro -1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-1-isoindolinone and (+)-2-(7 -chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone.

Method for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone)

The present invention relates to methods for making racemic 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-1-isoindolinone and (+)-2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone.

Methods for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2oxo-hexyl)-1-isoidolinone

Methods for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone

An improved process for the preparation of 5-(4-fluorophenyl)-1-&lsqb;2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl&rsqb;-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.

Process for the synthesis of 5-(4-fluorophenyl)-1-&lsqb;2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl&rsqb;-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide

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Lindenhurst, IL, United States of America

Timothy L Stuk