University of California

Neuralink, Corp.

Timothy L Hanson

Philip N Sabes

Michel Martin Maharbiz

Ian M O'Hara

Vikash Gilja

Kenny Sharma

Timothy J Gardner

Methods are provided for the fabrication of microneedles. Microneedles fabricated according to the herein described methods will generally be constructed of multiple lengths of wire winded together, brazed and further manipulated to include a reversible engagement feature. The subject microneedles may find use in a variety of applications and, among other purposes, the reversible engagement feature of such a microneedle may by employed in implanting an implantable device into a biological tissue. Also provided are methods of inserting an implantable device into a biological tissue having an outer membrane. The subject methods may include ablating a section of the outer membrane and inserting the implantable device through the ablated section of outer membrane, including e.g., where the implantable device is inserted using a microneedle including e.g., those microneedles for which methods of fabrication are provided herein.

Microneedle fabrication and device implantation

Methods, systems, and compositions are provided for implanting an implantable device into a biological tissue (e.g., muscle, brain). A subject implantable device includes: (i) a biocompatible substrate, (ii) a conduit (e.g., an electrode, a waveguide) that is disposed on the biocompatible substrate, and (iii) an engagement feature (e.g., a loop) for reversible engagement with an insertion needle. The biocompatible substrate can be flexible (e.g., can include polyimide). The implantable device is implanted using an insertion needle that includes an engagement feature corresponding to the engagement feature of the implantable device. To implant, an implantable device is reversibly engaged with an insertion needle, the device-loaded insertion needle is inserted into a biological tissue (e.g., to a desired depth), and the insertion needle is retracted, thereby disengaging the implantable device from the insertion needle and allowing the implantable device to remain implanted in the biological tissue.

Methods, compositions, and systems for device implantation

Systems and methods that use computer vision techniques in connection with robotic surgery are discussed. A robotic surgery system may include an implantable device engagement sub-system, a targeting sub-system, and/or an insertion verification sub-system. The system may use computer vision techniques to facilitate implanting a micro-manufactured bio-compatible electrode device in biological tissue (e.g., neurological tissue such as the brain) using robotic assemblies. The system can attach, via robotic manipulation, the electrode to an engagement element of an insertion needle. The system can further irradiate the electrode using a near-ultraviolet (near-UV) wavelength of light, obtain images of the electrode with light fluoresced from the polymer portion in response to the irradiating, triangulate a 3D location of the electrode, analyze a target tissue contour using computer vision, select an insertion site, and surgically implant the micron-scale electrode at the insertion site via robotic assembly and based on the triangulated location.

Computer vision techniques

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San Francisco, CA, United States of America

Timothy L Hanson