Merck Sharp + Dohme Corp.

Merck Frosst Canada & Co.

Merck Sharpe & Dohme Corp.

Merck & Dohme Limited

Timothy Jason Sparey

Timothy Harrison

Martin Richard Teall

Andrew Madin

Ian James Collins

Alan John Nadin

Michael Rowley

Stephen Robert Fletcher

Paul David Leeson

Christopher Richard Moyes

Stephen John Lewis

Joanne Claire Hannam

Jose Luis Castro Pineiro

Brian John Williams

Andrew Pate Owens

Patrice C Belanger

Adrian Leonard Smith

Graeme Irvine Stevenson

Ian Churcher

Alexander Richard Guiblin

Joanne Clare Hannam

Susannah Williams

Joseph George Neduvelil

Mark Steven Shearman

Edward Giles McIver

Sonia Kerrard

A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease.

Sulphonamido-substituted bridged bicycloalkyl derivatives

There is disclosed a novel class of sulphonamido-substituted bridged bicycloalkyl derivatives comprising a substitute on the bridgehead position. The compounds modulate the production of the &#x3b2;-amyloid precursor protein, and hence are useful in the treatment of Alzheimer's Disease.

Sulphonamides for control of beta-amyloid production

Novel sulfamides of formula (I) are disclosed. The compounds exert an inhibitory action on the processing of APP by gamma-secretase, and are therefore useful in the treatment or prevention of Alzheimer's disease.

Sulfamides as gamma-secretase inhibitors

A novel class of 1,4- and 1,5-benzodiazepines of formula (I) is disclosed. The compounds modulate the processing of amyloid precursor protein by &#x3b3;-secretase, and hence find use in the treatment or prevention of conditions associated with the deposition of &#x3b2;-amyloid, such as Alzheimer's disease 

Benzodiazepine derivatives as APP modulators

Compounds according to Formula (I) or a salt thereof are selective ligands for GABA receptors useful for treatment of disorders of the central nervous system:

Substituted 1H-pyridinyl-2-ones as GABAA alpha 2/3 ligands

1,2,4-triazolo&lsqb;4,3-b&rsqb;pyridazine derivatives, represented by

Triazolo-pyridazine derivatives as ligands for GABA receptors

Substituted 1H-Pyridinyl-2-ones are useful as GABA,-Alpha 2/3 ligands.

Substituted 1H-pyridinyl-2-ones as GABAA-&agr; 2/3 ligands

Phenylbenzimidazole derivatives as ligands for GABA receptors

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Timothy Jason Sparey