Merck Sharp + Dohme Corp.

Merck Sharpe & Dohme Corp.

Timothy James Wright

Peter Emmanuel Maligres

Guy R Humphrey

John Y L Chung

James Francis Dropinski

Artis Klapars

Edward Cleator

John Limanto

Edward C Sherer

Cheol Keun Chung

Faye Sheen

Bryon Ladd Simmons

Aaron J Moment

Neil A Strotman

Michael Shevlin

Shane W Krska

Gavin William Stewart

Alan Michael Hyde

Carl A Baxter

Susan L Zultanski

Ralph Calabria

Amude Kassim

Daniel A DiRocco

Mikhail Reibarkh

Debra J Wallace

Yi Ning Ji Chen

Tyler A Davis

Louis Charles Campeau

Rose Mathew

The present invention is directed to a process for making Chloro-Substituted Nucleoside Phosphoramidate Compounds of formula (I): which are useful for the treatment and prophylaxis of HCV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).

Process for making chloro-substituted nucleoside phosphoramidate compounds

An efficient process is disclosed for producing the compound of formula I, which is the CETP inhibitor anacetrapib, which raises HDL-cholesterol and reduces LDL-cholesterol in human patients and may be effective for treating or reducing the risk of developing atherosclerosis: 

Process for synthesizing a CETP inhibitor

The present invention is directed to processes for preparing a diazepane compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is further directed to crystalline forms of this diazepane compound and pharmaceutical compositions thereof.

Process for the preparation of an orexin receptor antagonist

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Clark, NJ, United States of America

Timothy James Wright