Therics, Inc.

Integra Lifesciences Corporation

Massachusetts Institute of Technology

Theries, LLC

Timothy J Pryor

Peter A Materna

Christopher M Gaylo

Ronald T Ingram

Jignesh B Patel

Michael John Cima

Qing Wen Liu

Thomas George West

Jaedeok Yoo

James A Fairweather

Thomas J Bradbury

Douglas E Weitzel

Henry Leon Surprenant

Donald C Monkhouse

James Iskra

Chen-Chao Wang

Ireneusz J Imiolek

Jeffrey A Fedor

Alfred Anthony Litwak

Kathleen D Chesmel

Sunil Saini

Jennifer Patterson

Patrick Teung

Heather Ann Beam

This invention relates to a flowable collagen/glycosaminoglycan (GAG) material including particles of collagen/GAG matrix that, when hydrated, can be effectively delivered to wounds having varying depths and geometries. The flowable collagen/GAG matrix allows a more intimate contact between the wound matrix and the wound bed, and provides a structural framework that serves as a scaffold for cell ingrowth.

Flowable wound matrix and its preparation and use

An engineered regenerative biostructure (erb) for implantation into a human body as a bone substitute, which includes an internal microstructure, mesostructure and/or macrostructure to provide improved bone in-growth, and methods for making the erb. Under one aspect of the invention, the biostructure has resorbable and nonresorbable regions. Under another aspect of the invention, the biostructure is constructed of hydroxyapatite, tricalcium phosphate and/or demineralized bone. Under yet another aspect of the invention, the porous biostructure is partially or fully infused with a resorbable, nonresorbable or dissolvable material.

Method and apparatus for engineered regenerative biostructures such as hydroxyapatite substrates for bone healing applications

Apparatus, systems and methods for use in three-dimensional printing are shown and described. Various embodiments of the invention allow for more precise and controlled delivery of heat to achieve interlayer drying; isolation of the working region from the outside for reasons of cleanliness and in connection with the vapors of organic solvents; better control of the temperature of the working region; better accuracy in the flowrates of binder fluid dispensed; matching of delivered flowrates for multiple dispensers; verification of delivered flowrate or drops; provision for easier changeover of the machine from one powder to another; cleanability; and other needs.

Apparatus, systems and methods for use in three-dimensional printing

A device for controlling or altering the temperature of a liquid at the point of dispensing. A temperature-altering device is thermally coupled to a dispensing device to compensate for heat dissipated into the liquid as it passes through the dispensing device during dispensing. The dispensing device may be for example, a miniature solenoid valve (microvalve), a piezoelectric printhead, or the like. According to aspects of the invention, a temperature-altering device provides or reduces heat at the point of dispensing in order to alter, control or maintain a constant temperature of the dispensed liquid. As a result, improvement is obtained in the consistency of the fluid regime of the dispensed droplet stream. The temperature-altering device may be a thermoelectric device capable of moving heat either from or to the dispensing structure, or may be a heater. This device may be used beneficially even when the dispensing is performed near room temperature and the liquid does not require heating to maintain its liquid state.

Method and system for controlling the temperature of a dispensed liquid

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Yardley, PA, United States of America

Timothy J Pryor