Abbott Molecular Inc.

Abbott Laboratories Corporation

Fenwal, Inc.

Timothy J Patno

John T Foley

Sonal Sadaria Nana

Mark A Talmer

Joseph P Skinner

Daniel J Harris

Jason E Bryant

Frank Pawlowski

Brett W Johnson

David M Peters

Daniel P Casazza

Eric Yeaton

Eric B Shain

Timothy P Henning

Chadwick M Dunn

Timothy A Johnson

Wesley W Addison, Ii

Matthew J Hayes

Jody L Keck

David L Bonnett

Robert J Cantu

Russell D Stinaff

Jennifer A Hollenstein

Austin Lines

Dean Khan

Ali Attarwalla

Michael Giraud

Eric D Yeaton

Michael S Hazell

Robert Cairone

Wesley W Addison Ii

Aspects of the present disclosure include sample analysis methods and systems. According to certain embodiments, provided are methods of analyzing samples in an automated sample analysis system. The methods include introducing samples and sample preparation cartridges into the system, isolating and purifying an analyte (e.g., nucleic acids and/or proteins) present in the samples at a sample preparation station, and performing analyte detection assays in assay mixtures that include the purified analyte. Also provided are automated sample analysis systems that find use, e.g., in performing the methods of the present disclosure. In certain aspects, the methods and systems provide for continuous operator access during replenishment or removal of one or any combination of samples, bulk fluids, reagents, commodities, waste, and/or the like.

Systems and methods for automated analysis

The instant disclosure provides nucleic acid amplification systems and multi-reaction analysis systems useful in the efficient processing of samples, including clinical samples. Integrated systems that include nucleic acid amplification devices functionally combined with multi-reaction analysis systems are also included. Also provided are methods for monitoring multiple concurrent nucleic acid amplification reactions that include the use of devices and systems described herein.

Nucleic acid amplification and detection devices, systems and methods

Aspects of the present disclosure include sample preparation cartridges including a frame that includes a plurality of wells integrated therewith, where the plurality of wells have a closed bottom and an open top. The frame further includes an opening within the frame having a reaction vessel (RV) or RV cap removably disposed therein, where the plurality of wells and the opening are linearly arranged relative to each other. Also provided are sample preparation cartridges that include a frame, two or more cartridge separation projections on a top side of the frame, and two or more cartridge separation projections on a bottom side of the frame. The cartridge separation projections separate the cartridge and a different cartridge when the cartridge and different cartridge are stacked. Methods of using the sample preparation cartridges, as well as nucleic acid sample preparation units that include the sample preparation cartridges, are also provided.

Sample preparation cartridges and methods for using same

Systems and methods for controlling fluid flow during a fluid exchange procedure. In one aspect, a system is provided for controlling a net fluid volume difference of a patient during and/or after a fluid exchange procedure. The system comprises a first flow path for flowing at least a first fluid from the patient and a second flow path for flowing at least a second fluid to the patient. First and second reservoirs are respectively associated with the first and second flow paths. A controller is associated with the first and second flow paths for controlling first and second flow rates and operable to determine an actual flow rate for each first and second fluid and to change a first or second flow rate in response to a difference between at least one of such flow rates and its respective actual flow rate.

System and method for controlling patient fluid balance and/or flow rate for a therapeutic plasma exchange procedure

Growing community of inventors

Barrington, IL, United States of America

Timothy J Patno