Carrus Capital Corporation

Micrologix Biotech Inc.

Migenix, Inc.

Timothy J Krieger

Patricia J McNicol

Janet R Fraser

Robert Taylor

Douglas Erfle

Michael H P West

Dale R Cameron

Yuchen Chen

Evelina Rubinchik

Maria Marta Guarna

Sonia K Pawlak

Shafique Fidai

Patricia J McNichol

Antimicrobial and/or anti-inflammatory peptide compositions and therapeutic uses thereof are provided. The peptides and analogs or derivatives thereof may be used as an antimicrobial agent and/or as an anti-inflammatory agent. In certain embodiments, the peptides are cationic peptides. The peptides are useful for the treatment of inflammatory diseases, such as microorganism-caused infections, acne, and psoriasis. The peptides and peptide formulations may be used topically or parenterally.

Antimicrobial and anti-inflammatory peptides

Compositions and methods for making and using therapeutic formulations of antimicrobial cationic peptides are provided. The antimicrobial cationic peptide formulations may be used, for example, in the treatment of microorganism-caused infections, which infections may be systemic, such as a septicemia, or may be localized, such as in acne or an implanted or indwelling medical device.

Antimicrobial cationic peptides and formulations thereof

Compositions and methods for treating infections, especially bacterial infections, are provided. Indolicidin peptide analogues containing at least two basic amino acids are prepared. The analogues are administered as modified peptides, preferably containing photo-oxidized solubilizer.

Compositions and methods for treating infections using analogues of indolicidin

Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics

Growing community of inventors

Lowell, MA, United States of America

Timothy J Krieger