Merck Sharp + Dohme Corp.

Merck + Co., Inc.

Almac Discovery Limited

Johnson Controls Tyco IP Holdings Llp

Other

Tyco Fire & Security Gmbh

Merck Frosst Canada & Co.

Merck Sharpe & Dohme Corp.

Almac House

Merck & Dohme Limited

Dohme Ltd.

Merck Sharp

Timothy Harrison

Brian John Williams

Christopher John Swain

Raymond Baker

Martin Richard Teall

Alan John Nadin

Janusz Jozef Kulagowski

Andrew Madin

Eileen Mary Seward

Andrew Pate Owens

Neil Roy Curtis

Jason Matthew Elliott

Gregory John Hollingworth

Philip Stephen Jackson

Ian James Collins

Nadia Melanie Rupniak

Jose Luis Castro Pineiro

Timothy Jason Sparey

Duncan Edward Shaw

Ian Churcher

Paul E Finke

Paul Joseph Oakley

Frank Burkamp

Sander G Mills

Shrenik K Shah

Conrad P Dorn

Jeffrey John Hale

Tamara Ladduwahetty

Kevin Dinnell

Sonia Kerrad

Malcolm MacCoss

Mark Peter Ridgill

Colin O'Dowd

Susannah Williams

Mark Stewart Chambers

James Samuel Shane Rountree

Angus Murray MacLeod

Michael Rowley

Christopher Richard Moyes

Frederick Michael McBride

Alexander Richard Guiblin

Joanne Clare Hannam

Joanne Claire Hannam

Mark Steven Shearman

Eileen May Seward

Lixin Zhang

Graham Peter Trevitt

Leslie Joseph Street

William Robert Carling

Richard Thomas Lewis

Stephen Robert Fletcher

Kevin William Moore

Mark Stuart Chambers

Paul David Leeson

Graeme Irvine Stevenson

Michael Geoffrey Russell

Stephen John Lewis

Linda Elizabeth Keown

Laura Catherine Cooper

Peter Hewitt

Gayle Scott

Hugues Miel

Matthew Duncan Helm

Huw David Lewis

Christopher Hamblett

Jed Hubbs

Peter Alan Hunt

Simon Neil Owen

Richard Alexander Jelley

Joseph George Neduvelil

Frederick Michael Mcbride

Mary Melissa McFarland

Christina Bell

Steven David Shepherd

Lauren Emma Proctor

Susannah William

Stephen Colin Price

Malcolm Maccoss

Hazel Joan Dyke

Patrice C Belanger

David James Hallett

Richard Leonard Elliott

Calum MacLeod

Simon Charles Goodacre

Adrian Leonard Smith

Toby Jonathan Blench

Michela Bettati

Edward Giles McIver

Yudith Garcia

Andrew Wilkinson

Joanne Thomson

Adam Piotr Treder

Karl Richard Gibson

James Michael Crawforth

Mark Peter Bell

Sumita Bhattacharyya

Phillip Smith

Sonia Kerrard

Graham Trevitt

Peter Robin Hewitt

The present invention relates to compounds of Formula (I) that are useful as inhibitors of the activity of the ubiquitin specific protease USP19. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in therapy.

Pharmaceutical compounds

A sensor system includes: a housing having an internal wall defining an opening; a transparent window mounted within the opening; a sensor device within the housing and having at least one of a sensor output or a sensor input alignable with the transparent window; a vibration device in communication with the transparent window, where the vibration device is controllable to produce a first sonic movement; where the transparent window is movably responsive to the first sonic movement with a second sonic movement; and at least one damping member located between the transparent window and the sensor device, where the damping member substantially isolates the sensor device from at least the second sonic movement of the transparent window. A method includes determining a cleaning trigger corresponding to cleaning the transparent window; and controlling, in response to the cleaning trigger, a vibration frequency, amplitude, or duration of the vibration device.

Sensor system having transparent window contaminant removal using vibration

The present invention relates to receptor tyrosine kinase-like orphan receptor 1 (ROR1) specific antigen binding molecules and associated fusion proteins and conjugates. In a further aspect, the present invention relates to conjugated immunoglobulin-like shark variable novel antigen receptors (VNARs).

ROR1-specific antigen binding molecules

Inhibitors of ubiquitin specific protease 19 (USP19) of Formula (I) are provided, together with pharmaceutical compositions comprising said inhibitors, and methods of use thereof. The compounds can be used in in the treatment of muscular atrophy, obesity, insulin resistance or type II diabetes or in reducing the loss of muscle mass.

4-hydroxypiperidine derivatives and their use as inhibitors of ubiquitin specific protease 19 (USP19)

The present invention relates to compounds of Formula (I) that are useful as inhibitors of the activity of the ubiquitin specific protease USP19. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in therapy. 

The present invention relates to compounds that are useful as inhibitors of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer. 

Pyrimidopyrimidinones useful as Wee-1 kinase inhibitors

The invention relates to a series of compounds with particular activity as inhibitors of the serine-threonine kinase AKT. Also provided are pharmaceutical compositions comprising same as well as methods for treating cancer.

Inhibitors of AKT activity

The present invention relates to compounds that are useful as inhibitors of the activity of one or more isoforms of the serine/threonine kinase, AKT. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer.

AKT inhibitor compounds for treatment of cancer

Compounds of formula (I) are modulators of gamma-secretase, and hence are useful in treatment of Alzheimer's disease. 

Piperidines and related compounds for the treatment of Alzheimer's disease

Sulphones of formula (I) are disclosed for use in treatment of cancer. 

Cyclohexyl sulphones for treatment of cancer

Bridged bicyclic sulphamides of formula (I) are disclosed for treatment of cancer. 

Sulphamides for treatment of cancer

Compounds of formula I: are disclosed. The compounds are useful in treating or preventing diseases associated with deposition of A&#x3b2; in the brain.

(4, 5, 6, 7-tetrahydro-1-H-indol-7-yl) acetic acid derivatives for treatment of Alzheimer's disease

Growing community of inventors

Great Dunmow, United Kingdom

Timothy Harrison