Astrazeneca Ab

Timothy Gordon Rasmusson

Jason Grant Kettle

Johannes Wilhelmus Maria Nissink

Bin Yang

Gillian McGregor Lamont

Thomas George Christopher Hayhow

Charlene Fallan

The specification generally relates to compounds of Formula (I): and pharmaceutically acceptable salts and prodrugs thereof, where R, R, R, R, R, Linker, X, Y, A, G, D and E have any of the meanings defined herein. This specification also relates to the use of such compounds and pharmaceutically acceptable salts and prodrugs thereof in methods of treatment of the human or animal body, for example in prevention or treatment of cancer. This specification also relates to processes and intermediate compounds involved in the preparation of such compounds and to pharmaceutical compositions containing them.

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Wilmington, DE, United States of America

Timothy Gordon Rasmusson