Medtronic, Inc.

Medtronic Cryocath LP

Medtronic Ablation Frontiers LLC

Cardioinsight Technologies, Inc.

Ford Motor Company Limited

Medtronics, Inc.

Trw Vehicle Safety Systems Inc.

Medronic, Inc.

Timothy G Laske

Timothy R Ryan

Charles P Tabor

Mark T Stewart

Carol Elsa Eberhardt

Gonzalo Martinez

Paul Anthony Iaizzo

Joseph C Morrow

Brian A Glynn

Tammy Y Tam

Regina E Groves

Alexander J Hill

Anne L Brody Rubin

Jean-Pierre Lalonde

Matthew David Bonner

Mary M Morris

Qingguo Zeng

Michael R Ujhelyi

Claudia Lueckge

Qing Lou

Michael J Tuchek

Dan Wittenberger

Terrell M Williams

Gregory A Boser

Pedro A Meregotte

Ramin Sabbaghe-Kermani

James R Keogh

Eliot F Bloom

Carolyn C Majkrzak

Bret R Shoberg

Mark Allen Benscoter

Jon Virgil Evans

Xiaoyi Min

Paul T Rothstein

Kenneth Timothy Heruth

Mark T Marshall

David E Francischelli

Kenneth C Gardeski

Cynthia T Clague

Steven Lawrence Waldhauser

James R Skarda

John G Keimel

Allen J Tower

Jon M Ocel

Jack D Lemmon

Mark A Hjelle

Roger P Daniel

Michael M Green

Michael E Leckrone

John Louis Sommer

Kevin R Seifert

Ping Jia

James F Kelley

Ryan M Bokan

Daniel C Sigg

Douglas N Hess

Peter M Mulier

David W Mayer

John Bischof

Kenneth W Keeney

Catherine E Taylor

Damian Jelich

Linda L Lach

Jesus W Casas-Bejar

Michael A Ruff

David S Olson

Andrew J Ries

John Matthew Swoyer

Vinod Sharma

John R Liddicoat

Louis R Brown

Orhan Soykan

Peter M J Mulier

Raja N Ghanem

Mahmoud Kabir Seraj

Thomas C Bischoff

David Lipson

George J Klein

Brian P George

Richard D Sandstrom

Philipp Bonhoeffer

Nicolaas M Lokhoff

Elisabeth Lacy Belden

Asha Shrinivas Nayak

Cathleen A Bergin

Sarah E Ahlberg

Sandra F Viktora

Lea A Nygren

Chris M Coppin

Réal Ste-Marie

Dale A Wahlstrom

Mark W Torrianni

George Michael Huepenbecker

Michael R Dollimer

Ryan P Lahm

Rany Huynh

Jeffrey B Adair

Eric Meyer

David G Schaenzer

Connor S Edel

In an example, a signal segment evaluator can be programmed to evaluate a morphology of at least one electrophysiological signal to identify a signal segment of interest. The morphology of the signal segment of interest can be indicative of an electrophysiological event of a patient during a respective time interval. A reconstruction engine can be programmed to reconstruct electrophysiological signals on a surface of interest within a body of the patient based on the electrophysiological signals measured from an outer surface of the patient and geometry data representing an anatomy of the patient. A map generator can be programmed to generate a map representing the reconstructed electrophysiological signals on the surface of interest for the respective time interval of the signal segment of interest. A target generator can be programmed to identify a target site within the patient's body based on the map for the electrophysiological event.

Systems and methods for electrocardiographic mapping and target site identification

In a described example, a method includes identifying, by a processor, negative deflections of at least one unipolar signal representing cardiac electrical activity on a surface of interest during a respective interval of the at least one signal. The method also includes determining, by a processor, an activation time for a last identified negative deflection in the respective interval. The method also includes detecting, by the processor, an instance of late activation based on comparing the activation time to a temporal threshold.

Late activation of cardiac signals

A compressible and expandable stent assembly for implantation in a body lumen such as a mitral valve, the stent assembly including at least one stent barrel that is shaped and sized so that it allows for normal operation of adjacent heart structures. One or more stent barrels can be included in the stent assembly, where one or more of the stent barrels can include a cylinder with a tapered edge.

Stented heart valve devices and methods for atrioventricular valve replacement

The present invention relates to a method, device, and system for improved mapping and/or ablation of a tissue. The device may generally include an elongate body and a distal assembly affixed to the elongate body that includes a treatment electrode having a conductive mapping region and a selectively conductive ablation region that is conductive of high-frequency current and substantially non-conductive of low-frequency current. Alternatively, the device may generally include a treatment electrode having a conductive mapping or ablation region and a region that is coated with an electrically insulated but thermally conductive layer.

Electrophysiology catheter design

A computer-implemented method includes storing location data for at least one invasive electrode that is movable within a patient's body. The method also includes storing electrophysiological measurement data representing the electrophysiological signals measured at the outer surface of a patient's body by body surface electrodes and within the patient's body by the at least one invasive electrode. The method also includes storing geometry data representing anatomy of the patient spatially, and locations of the respective body surface electrodes and the at least one invasive electrode in three-dimensional space. The geometry data for the at least one invasive electrode can vary based on movement of the at least one invasive electrode within the patient's body. The method also includes reconstructing electrophysiological signals on a surface of interest within the patient's body based on the electrophysiological measurement data and the geometry data.

Monitoring and analysis of invasive and non-invasive electrophysiological signals

A stented valve including a generally tubular stent structure that has a longitudinal axis, first and second opposite ends, a plurality of commissure support structures spaced from the first and second ends and extending generally parallel to the longitudinal axis, at least one structural wire positioned between each two adjacent commissure support structures, and at least one wing portion extending from two adjacent commissure support structures and toward one of the first and second ends of the stent structure. The stented valve further includes a valve structure attached within the generally tubular stent structure to the commissure support structures.

Stents for prosthetic heart valves

A device, system, and method for optically evaluating and treating or ablating tissue. Specifically, device, system, and method allow for the optical and/or electrical evaluation of tissue at the same location(s) at which ablation or treatment or ablation energy is delivered. This allows for a more accurate evaluation of lesion formation and tissue condition before, during, and/or after a treatment or ablation procedure. In one embodiment, a device for performing a medical procedure includes an elongate body including a proximal portion, a distal portion having a distal end, and a longitudinal axis, and a distal tip electrode at the elongate body distal end, the tip electrode being optically transparent and electrically conductive. The device may also include optical windows in the elongate body aligned with one or more transparent lateral electrodes for optically interrogating tissue and/or for delivering treatment or ablation energy to tissue.

Ablation catheter with dual optical-electrical stimulation and sensing

An example method includes establishing a communications link between an electrophysiology (EP) monitoring system and an implantable medical device (IMD). IMD electrical data is received at the monitoring system via the communications link. The IMD electrical data may be synchronized with EP measurement data to provide synchronized electrical data based on timing of a synchronization signal sensed by an IMD electrode and/or EP electrodes. The method also includes computing reconstructed electrical signals for locations on a surface of interest within the patient's body based on the synchronized electrical data and geometry data. The geometry data represents locations of the EP electrodes, a location of the IMD electrode within the patient's body and the surface of interest.

Using implantable medical devices to augment noninvasive cardiac mapping

A stented valve including a generally tubular stent structure that has a longitudinal axis, first and second opposite ends, a plurality of commissure support structures spaced from the first and second ends and extending generally parallel to the longitudinal axis, at least one structural wire positioned between each two adjacent commissure support structures, and at least one wing portion extending from two adjacent commissure support structures and toward one of the first and second ends of the stent structure. The stewed valve further includes a valve structure attached within the generally tubular stent structure to the commissure support structures.

Systems and methods for controllably variable fluid flow are disclosed that provide the ability to modify the effective cross-sectional area of the fluid delivery conduit available for fluid flow. Accordingly, selective control of these configurations allows fluid flow to be regulated as desired while the fluid delivery pressure remains the same. Additional configurations provided herein allow for the selective manipulation of a footprint or therapeutic pattern achievable with the medical device during a single procedure, negating the need for the removal and insertion of multiple devices to achieve the same variations in treatment geometry or characteristics.

Systems and methods for variable injection flow

Systems and methods for cardiac fast firing (e.g., atrial fast firing) detection perform frequency analysis on channels of collected cardiac waveform data and test the data for outlier frequency complex content that is of higher frequency than baseline frequency complex content associated with cardiac fibrillation (e.g., atrial fibrillation) or other arrhythmogenic activity. Anatomical regions from whence the cardiac fast firing originates can be displayed in real time on an epicardial surface map via a graphical display, aiding administration of therapy. Prior to such detection, QRST complex removal can be performed to ensure that ventricular activity does not infect the atrial fast firing analysis. A frequency-based method for QRST complex removal is also disclosed.

Detection and localization of cardiac fast firing

A method and system for providing lesion depth feedback during an ablation procedure. In particular, the method and system provide feedback data or information relating to lesion depth in myocardial tissue during a cryoablation procedure. A plurality of tissue temperature measurements may be transmitted from a plurality of thermocouples disposed on a cryotreatment element, which measurements may be used to determine a slope of change in temperature sensed by each thermocouple over time. The circulation of coolant through the treatment element may be adjusted when the slope changes. A change in slope may indicate that the cryoablation temperatures have passed through target myocardial tissue into non-target, non-myocardial tissue, which may result in collateral damage to structures near the heart.

Feedback system for cryoablation of cardiac tissue

A delivery system for an implantable stented device having a handle with a plurality of actuation members, each actuation member connected to one or more stent attachment elements, a sheath having a proximal end attached to the handle, and a plurality of tubes extending within the sheath. The stent attachment elements extend from distal ends of the tubes. A first actuation member is configured to move a first stent attachment element proximally toward the handle and a second actuation member is configured to move a second stent attachment element proximally toward the handle, sequentially releasing specific portions of the stented device by causing distal ends of the stent attachment elements to contact an exterior of the distal ends of the tubes, thereby disengaging the first and second stent attachment elements from the stented device.

Delivery systems and methods of implantation for prosthetic heart valves

Growing community of inventors

Shoreview, MN, United States of America

Timothy G Laske