Juno Therapeutics Gmbh

Editas Medicine, Inc.

Timothy G Johnstone

Mark L Bonyhadi

Stephen Jacob Goldfless

Cameron Brandt

Brian J Belmont

Blythe D Sather

Ryan P Larson

Melissa Works

Yue Jiang

Lucas James Thompson

Ruth Salmon

Alexandra Croft

Michael Ports

Jon Jones

Ronald James Hause, Jr

Gordon Grant Welstead

Stephen Michael Burleigh

Christopher Heath Nye

Haley Peper

David Jeffrey Huss

James Sissons

Dean Y Toy

David G Kugler

Queenie Vong

Neha Soni

Christopher Borges

David Koppstein

Hieu Nguyen

Sonia Timberlake

Oleksandr Baturevych

Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.

HPV-specific binding molecules

Provided herein are methods of identifying genomic region(s) predictive of an outcome of treatment with a cell therapy and/or of a phenotype of function of the cells. In some embodiments, the methods include epigenetic and/or epigenomic analyses of the cells in connection with methods for preparing engineered cells for cell therapy and/or predicting response to a cell therapy, e.g., engineered cells for cell therapy. In some embodiments, the methods include steps to assess, characterize and analyze changes or modifications in an epigenetic property of gene region or regions, such as chromatin accessibility, nucleosome occupancy, histone modification, spatial chromosomal conformation, transcription factor occupancy and/or DNA methylation. In some embodiments, the epigenetic and/or epigenomic analysis includes determining the epigenetic properties of a cell, e.g., an engineered cell for cell therapy.

Epigenetic analysis of cell therapy and related methods

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Seattle, WA, United States of America

Timothy G Johnstone