Mcgill University

Elanco US Inc.

Ah USA 42 LLC

Timothy G Geary

Roger K Prichard

Catherine Bourguinat

Peter Rolfe

Disclosed are nucleic acid molecules from the genome ofspp. nematodes that contain single nucleotide polymorphisms related to reduced responsiveness of the nematodes to macrocyclic lactones. In one example, the species ofis(the agent of heartworm in animals). Also disclosed are methods for determining the responsiveness ofspp. nematodes to macrocyclic lactones, methods for selecting a treatment to treat an animal infected withspp. nematode, and kits for determining the responsiveness ofspp. nematodes to macrocyclic lactones.

Markers to predict macrocyclic lactone drug resistance in, the causative agent of heartworm disease

Disclosed are nucleic acid molecules from the genome ofspp. nematodes that contain single nucleotide polymorphisms related to reduced responsiveness of the nematodes to macrocyclic lactones. In one example, the species ofis(the agent of heartworm in animals). Also disclosed are methods for determining the responsiveness ofspp. nematodes to macrocyclic lactones, methods for selecting a treatment to treat an animal infected with aspp. nematode, and kits for determining the responsiveness ofspp. nematodes to macrocyclic lactones.

Markers to predict macrocyclic lactone drug resistance in dirofilaria immitis, the causative agent of heartworm disease

A composition comprising 2-desoxoparaherquamide and abamectin for the treatment of a parasitic infestation in mammals.

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Timothy G Geary