Becton Dickinson and Company Limited

Timothy G Bloomster

Gloria J Covington

Robert W Rosenstein

Hans H Feindt

Gerald D Hahn

S Melissa Maret

A test device for use in determining analyte wherein binder is supported on a solid support in admixture with a marker whereby the presence and location of binder on the support can be determined prior to the assay. A control for the assay may also be applied to the support in admixture with a label.

Depositing a binder on a solid support

A system having a coating station comprised of a dispensing assembly and a fluid collection head is useful in a method to precisely coat reagents on porous supports for use in diagnostic devices. In the method, a cover having an aperture therethrough and the porous support secured to its underside covering the aperture is positioned in the coating station between the dispensing assembly and the fluid collection head. The reagent is dispensed from a cannula in the dispensing assembly onto the portion of the porous support exposed through the aperture of the cover. A reduced pressure in the fluid collection head pulls fluid through the porous support. The system is automated by providing a guide channel for holding a plurality of covers in correct orientation and a magazine for holding a stack of covers. An indexing arm delivers the bottom-most cover in the stack to the guide channel and urges covers in the channel along its length. The system includes a reciprocating cylinder to bring the dispensing assembly and fluid collection head to the cover for coating and away from the cover after coating. The dispensing assembly may include a template for coating the reagent in a distinct pattern. The system can include a plurality of coating stations to permit coating with a plurality of reagents.

System and process for spotting reagents on porous supports

Test device and assay for determining analyte wherein tracer and sample may be simultaneously applied to different absorbent material portions both in capillary flow communication with an absorbent material portion having a binder supported thereon in a manner whereby sample contacts binder, prior to any substantial contact between sample and tracer or tracer and binder.

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Reistertown, MD, United States of America

Timothy G Bloomster