Harvard College

Massachusetts Institute of Technology

Novartis Ag

Millennium Pharmaceuticals Limited

Timothy F Jamison

Stuart L Schreiber

Christian A Hassig

Jack Taunton

Robert F Standaert

Gabriel Fenteany

Klavs F Jensen

Andrea Adamo

Jie Chen

Ping Zhang

Eric N Jacobsen

Allan Stuart Myerson

Jean-Christophe Monbaliu

Yutaka Ikeuchi

David R Snead

Scott E Schaus

Torsten Stelzer

Nopphon Weeranoppanant

Shin Yee Wong

Mohsen Behnam

Alexander G Dossetter

Eve Marie Revalor

Trevor Alan Hatton

Sze-Sze Ng

Oljan Repic

Dale Arlington Thomas, Iii

Matthew W Bedore

Fritz Simeon

Nikolay Zaborenko

Kosisochukwu C Aroh

Megan Alene Foley

Jie Wu

Jennifer Aiden Kozak

Eric Alan Standley

Aaron A Bedermann

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients

The instant disclosure is related to fluidic distributors, fluidic systems, and associated methods and articles. Certain embodiments are related to fluidic distributors that comprise bays including fluidic connections with relative positions that substantially correspond to each other. In some embodiments, a fluidic distributor may comprise bays with electrical interfaces with relative positions that substantially correspond to each other.

Reconfigurable multi-step chemical synthesis system and related components and methods

Described herein are nickel pre-catalysts and related compositions and methods. The nickel pre-catalysts may be activated to form catalysts which may be utilized in organic reactions.

Nickel pre-catalysts and related compositions and methods

The present invention generally relates to methods for the synthesis of catalysts, including epoxidation catalysts, and related compounds and catalyst compositions. Embodiments described herein may provide efficient processes for providing catalysts (e.g., epoxidation catalysts) in large quantities and using simplified methods.

Epoxidation catalysts

Described herein are inventive methods for synthesis of cyclic carbonates from COand epoxide. In some embodiments, the methods are carried out in the presence of a catalyst comprising an electrophilic halogen. In some embodiments, the methods are carried out in a flow reactor.

Methods and systems for the formation of cyclic carbonates

The present invention provides various methods for the synthesis of chemical species in a microreactor environment. In some cases, reaction products of the present invention may be valuable as intermediates and/or products in pharmaceutical and polymer research. For example, the method may involve the synthesis of amino alcohols within a microchannel. Embodiment described herein may allow for reactions with significantly shorter reaction times and increased efficiency.

Continuous flow synthesis of amino alcohols using microreactors

The present invention provides a novel process for opening a lactone and/or a lactam ring. More particularly, the present invention provides a process that employs a novel catalyst in the opening of a lactone ring and/or a lactam ring. Additionally, the present invention also provides a novel deprotection process of any protecting group present in either the lactone ring-containing and/or lactam ring-containing compound and/or in the ring-opened product thereof.

Ring opening of lactones and lactams

The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.

Histone deacetylases, and uses related thereto

The present invention relates to new compositions and reactions to produce allylic alcohols or precursors of allylic alcohols (e.g., silyl ethers of allylic alcohols). Methods of the invention may comprise combining an alkene and an aldehyde in the presence of a transition metal catalyst (e.g., a nickel catalyst) to form an allylic alcohol or precursor of an allylic alcohol. Reaction products of the present invention may be valuable as intermediates and/or products in pharmaceutical and polymer research. Also, methods of the invention may be useful as fragment coupling reactions in complex molecule synthesis. Moreover, methods of the invention may include the use of reagents which, under reaction conditions known in the art, may have been unreactive, i.e., may not have been able to form the reaction product. The reagents used in the present invention may be relatively lower in cost than in other methods. Also, methods of the invention may reduce the number of synthetic and purification steps required to produce the reaction products, as well as reducing time, cost, and waste production.

Catalytic reactions involving alkenes

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Somerville, MA, United States of America

Timothy F Jamison