Amgen Inc.

Timothy David Osslund

Christi L Clogston

Twinkle R Christian

Elisabeth Freeman

Linda Owers Narhi

Randal B Bass

Joyce Chi Yee Chan

Shon Lee Crampton

Scott Wasserman

Robert Andrew Donald Scott

John P Gibbs

Christian R Twinkle

John P Gibbs, Ii

Evan A Stein

Clapton S Dias

Robert Andrew Scott

Joyce Chi Chan

Discloses herein are high concentration antibody thrmulations comprising an anti-sclerostin immunoglobulin and an acetate salt and/or an acetate buffer and methods of use.

High concentration antibody formulations

Described herein are anti-PCSK9 antibody crystals, methods of making such antibody crystals and formulations comprising the antibody crystals.

Crystalline antibody formulations

Discloses herein are high concentration antibody formulations comprising an anti-sclerostin immunoglobulin and an acetate salt and/or an acetate buffer and methods of use.

Described herein are anti-sclerostin antibody crystals, methods of making such antibody crystals and formulations comprising the antibody crystals.

Sclerostin antibody crystals and formulations thereof

The present invention relates to granulocyte colony-stimulating factor ('G-CSF') hybrid molecules which retain the internal core helices of G-CSF. Also provided are pharmaceutical compositions containing hybrid molecules.

Modified G-CSF polypeptide

G-CSF analog compositions and methods

The present invention relates to crystalline etanercept and to methods of making crystalline etanercept; to pharmaceutical compositions comprising crystalline etanercept; and to therapeutic uses of such compositions.

Crystals of etanercept and methods of making thereof

The present invention concerns variants and chemical derivates of keratinocyte growth factor-2 (KGF-2) protein. Also disclosed are nucleic acid molecules encoding such variants, as well as methods for using such variants and chemical derivates to stimulate epithelial cell proliferation.

Keratinocyte growth factor-2 products

The present invention relates to granulocyte colony-stimulating factor (&ldquo;G-CSF&rdquo;) hybrid molecules which retain the internal core helices of G-CSF. Also provided are pharmaceutical compositions containing hybrid molecules.

The present invention relates to granulocyte colony-stimulating factor (&ldquo;G-CSF&rdquo;) analogs and compositions containing such analogs which retain the three-dimensional structure of the internal core of the four alpha helical bundle of G-CSF. In another aspect, such G-CSF analogs can also be attached with biologically active proteins to form hybrid molecules and still retain G-CSF structural integrity. Also provided are methods for determining and preparing analog or hybrid molecules and modifications.

G-CSF hybrid molecules and pharmaceutical compositions

The present invention is directed towards a computer apparatus for expressing a three dimensional structure of a G-CSF molecule or analogs thereof.

Growing community of inventors

Camarillo, CA, United States of America

Timothy David Osslund