Neurocrine Biosciences, Inc.

Ambit Biosciences Corporation

Timothy David Gross

Chen Chen

Zhiqiang Guo

Yun-Fei Zhu

Martin W Rowbottom

Fabio C Tucci

Achampeta Rathan Prasad

R Scott Struthers

Patrick B O'Donnell

Yinghong Gao

Patrick J Connors

Janakiram Rao Citineni

Rathan Prasad Achampeta

Solid forms comprising pyrazolylaminoquinazoline, compositions comprising the solid forms, methods of making the solid forms and methods of their use for the treatment of various diseases and/or disorders are disclosed. 

Solid forms comprising optically active pyrazolylaminoquinazoline, compositions thereof, and uses therewith

Provided herein are process for the preparation of N-(5-ferf-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-fe][1,3]benzothiazol-2-yl]phenyl}urea, or a pharmaceutically acceptable salt, solvate, hydrate, or polymorph thereof. N-(5-tert-Butyl-isoxazol-3-yl)-N&#x2032;-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-&][1,3]benzo-thiazol-2-yl]phenyl}urea is useful for treating, preventing, and/or managing diseases or conditions, including but not limited to, proliferative diseases, FLT-3 mediated diseases, and cancers. N-(5-ferf-Butyl-isoxazol-3-yl)-N&#x2032;-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-&][1,3]benzothiazol-2-yl]phenyl}urea is represented by the structure: 

Process for the preparation of imidazo[2,1-B][1,3]benzothiazole derivatives

Provided herein are hydrobromide salts of a pyrazolylaminoquinazoline, and pharmaceutical compositions thereof. Also provided are methods of their use for treating, preventing, or ameliorating a proliferative disease.

Hydrobromide salts of a pyrazolylaminoquinazoline

GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein A, Q, R, R, R, R, R, R, Rand n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure:wherein A, Q, R, R, R, R, R, R, Rand n are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

Growing community of inventors

San Diego, CA, United States of America

Timothy David Gross