Abbott Laboratories Corporation

Tap Pharmaceuticals, Inc.

Cortech, Inc.

Tap Holdings, LLC

Timothy D Fitzpatrick

Fortuna Haviv

Rolf E Swenson

Nicholas A Mort

Charles J Nichols

Jonathan Greer

Eric T Whalley

Val S Goodfellow

Manoj Vinayak Marathe

Christopher A Palabrica

Karen G Kuhlman

The present invention provides bradykinin type peptides containing N-substituted glycines, particularly bradykinin antagonist peptides useful for the treatment of conditions mediated by bradykinin including pain and inflammation.

Bradykinin antagonist peptides incorporating N-substituted glycines

6-position modified decapeptide LHRH antagonists

Decapaptide and undecapaptides substituted on the N-terminal nitrogen atom by acyl groups which include furo-2-yl, isonicotinyl, nicotinyl, 2-, 3-, and 4-quinolinecarbonyl, shikimyl, dihydroshikimyl, and tetrahydrofur-2-oyl are potent antagonists of LHRH and are useful for suppressing the levels of sex hormones in mammals.

N-terminus modified analogs of LHRH

The present invention provides a process for the preparation of peptides which have or side-chains containing an alkyl- or dialkyl-substituted guanidinyl group or a imidazinylamino or tetrahydropyrimidinylamino group. The process provides higher overall yields of peptide product by permitting the synthesis of the entire peptide chain prior to modification of the side-chain to introduce the groups.

Process for producing peptides with side chains containing

Decapaptides substituted on the N-terminal nitrogen atom by acyl groups are potent antagonists of LHRH and are useful for suppressing the levels of sex hormones in mammals.

The present invention relates to novel LHRH analogs. The LHRH analogs include 'pseudo' hexapeptide, heptapeptide, octapeptide and nonapeptide analogs of LHRH, wherein all or some of the amino acids, 1, 2 and 3 have been eliminated and the remaining (2-9), (2-10), (3-9), (3-10), (4-9) or (4-10) peptide is linked to various carboxylic acids which take the place of amino acids 1, 2 or 3 in LHRH.

Octapeptide LHRH antagonists

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Boulder, CO, United States of America

Timothy D Fitzpatrick