Commonwealth Scientific and Industrial Research Organisation

Novartis Ag

Other

Oregon Health & Science University

Technische Universitat Munchen

Centre Hospitalier Régional Universitaire De Lille

Medvet Science Pty Ltd

Université Victor Segalen—bordeaux 2

University of Heidelberg

Timothy Charles Hughes

Gordon Francis Meijs

Hassan Chaouk

Anthony Brian Clayton

Peter Agapitos Kambouris

Pathiraja Arachchillage Gunatillake

Graham M Johnson

John Gerard Steele

Brian Jay Druker

Justine Leigh Jeffery

Amie Corbin

John Stuart Wilkie

Martin Mueller

Jason Watling

Grace Yim Ngan Chan

Andreas Hochhaus

Sebastian Kreil

Christophe Barthe

Justus Duyster

Christian Peschel

Thibaut Leguay

Claude Preudhomme

Zbigniew Rudzki

Susan Branford

Catherine Roche Lestienne

A polymer comprising one or more macromonomer units selected from the group consisting of polysiloxane, perfluoroalkylpolyether (PFPE), fluorinated poly(meth)acrylate, polyalkyl (meth)acrylate, polyolefin and fluorinated polyolefin, and one or more charged units (such as an anionic, cationic or zwitter-ionic monomer), formed from a polymerization medium containing an aqueous solution of charged units and use of this polymer as an intraocular lens for the implantation into or onto the cornea. Another aspects relates to a process for coating the above polymer with an adhesive comprising covalently coupling co-reactive surface functional groups of a natural or synthetic polymer with functional groups present (or introduced) on the surface of the macromonomer containing polymer, followed by covalently coupling a multifunctionally activated compound having at least one functional group that is co-reactive to the reactive groups of the natural or synthetic polymer.

Polymer having charged units

The invention provides in one form a macromonomer comprising a polysiloxane copolymer having a backbone structure derived from siloxane monomer units that are substituted or unsubstituted arylsiloxanes, arylalkylsiloxanes, alky(alkyl)siloxanes of the general formula &#x2014;RRSiO&#x2014; and wherein the terminal groups of the copolymer backbone include crosslinkable groups and wherein pendent from the backbone are at least two crosslinkable groups. The macromonomer may be cured in vivo by ultraviolet or visible light. The invention includes intraocular lenses formed by such macromonomers.

Biomedical compositions

A hydrophilic ethylenically unsaturated macromonomer is disclosed that is prepared by the addition polymerization of addition polymerizable monomers that include monomers that have hydroxyl or amino functional groups, some of which may be subsequently reacted to provide (meth)acryl ethylenic unsaturation. The macromonomers may be used to form intraocular lenses in situ by polymerization of the macromonomers, and thus treat presbyopia.

Hydrophilic biomedical compositions

The present invention is concerned with biomedical device comprising The biomedical devices of the invention are radiation sensitive and may be used, for example, as ready-to-use corneal onlay in ophthalmic surgery.

Biomedical devices

A hydrophilic ethylenically unsaturated macromonomer is disclosed that is prepared by the addition polymerization of addition polymerizable monomers that include monomers that have hydroxyl or amino functional groups, some of which may be subsequently reacted to provide (meth)acryl ethylenic unsaturation. The macromonomers may be used to form intraocular lenses in situ by polymerization of the macromonomers.

Hydrophilic biomedical composition

The present invention relates to porous polymers incorporating dihydroperfluoroalkyl acrylates and methacrylates and the like and their production. The invention also relates to the use of polymers derived from dihydroperfluoroalkyl acrylates and methacrylates and like compounds, in both porous and non-porous forms, as substrates for the attachment and growth of mammalian cells and tissue. The invention also relates to the use of polymers derived from dihydroperfluoroalkyl acrylates and methacrylates as components of medical devices and prostheses, including implanted devices.

Biomaterials

Polymers

Growing community of inventors

Ferntree Gully, Australia

Timothy Charles Hughes