Provectus Pharmatech, Inc

Martin Marietta Energy Systems, Inc.

Lockheed Martin Energy Systems, Inc.

Photogen, Inc.

Xantech Pharmaceuticals, Inc.

Provectus Pharmaceuticals, Inc.

The United States of America As Represented by the United States

Timothy C Scott

Eric A Wachter

H Craig Dees

John T Smolik

Charles D Scott

Walter G Fisher

Brian H Davison

Michael T Harris

Jamie Singer

Marlon Lutz

Kevin Babiak

Osman A Basaran

Jonathan Woodward

Warren G Sisson

Charles H Byers

Brendlyn D Faison

Sahadeva Reddy Damireddi

J Robert Durrwachter

Hector M Lizama

Robert M Wham

John Smolik

Craig H Dees

A new process for the manufacture of iodinated xanthenes in high purity includes a cyclization step followed by an iodination step. No extraction, chromatographic or solvent concentration steps are required, and the intermediate as well as final compounds are isolated via filtration or similar means. The process requires a single organic solvent, and the steps are completed at temperatures below 100&#xb0; C. The exclusion of chloride ions, of chloride free-radicals, hypochlorite ions, or hypochlorous acid as reagents or from reagents that may generate these species in situ in the presence of oxidants, prevents undesirable impurity formation. Several new compounds have been conceived and isolated using these methods. These new compounds are also formed into new medicaments.

Process for the synthesis of 4,5,6,7-tetrachloro-3',6&#x2032;-dihydroxy-2&#x2032;,4&#x2032;,5&#x2032;,7&#x2032;-tetraiodo-3H-spiro[isobenzofuran-1,9&#x2032;-xanthen]-3-one(Rose Bengal) and related xanthenes

Process for the synthesis of 4,5,6,7-tetrachloro-3',6&#x2032;-dihydroxy-2&#x2032;, 4&#x2032;, 5&#x2032;7&#x2032;-tetraiodo-3H-spiro[isobenzofuran-1,9&#x2032;-xanthen]-3-one (Rose Bengal) and related xanthenes

New photodynamic, topically-applicable medicaments and certain medical uses of such photodynamic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene. The halogenated xanthenes constitute a family of potent photosensitizers that become photoactivated upon illumination of the treatment site with visible wavelengths of light. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs; the mouth and digestive tract and related organs; the urinary and reproductive tracts and related organs; the respiratory tract and related organs; various other internal or external tissue surfaces, such as tissue surfaces exposed during surgery; and for treatment of a variety of conditions related to microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid or aerosol delivery vehicles.

Topical medicaments and methods for photodynamic treatment of disease

New chemotherapeutic medicaments and certain medical uses and methods for use of such chemotherapeutic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. Preferably, the halogenated xanthene is Rose Bengal or a functional derivative of Rose Bengal. The halogenated xanthenes constitute a family of useful chemotherapeutic agents that afford selective, persistent accumulation in certain tissues. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations useful for intracorporeal or topical administration, including in liquid, semisolid, solid or aerosol delivery vehicles.

Medicaments for chemotherapeutic treatment of disease

Process for the synthesis of 4,5,6,7-tetrachloro-3',6&#x2032;-dihydroxy-2&#x2032;,4&#x2032;,5&#x2032;,7&#x2032;-tetraiodo-3H-spiro[isobenzofuran-1,9&#x2032;-xanthen]-3-one (rose bengal) and related xanthenes

New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. The halogenated xanthenes constitute a family of potent radiosensitizers that become photoactivated upon irradiation of the treatment site with ionizing radiation. In embodiments of the present invention, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.

Intracorporeal medicaments for high energy phototherapeutic treatment of disease

New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.

Intracorporeal medicaments for photodynamic treatment of disease

New diagnostic agents for positron emission tomography (PET) and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such agents is a radiolabeled halogenated xanthene or halogenated xanthene derivative. Preferably, the radiolabeled halogenated xanthene is radiolabeled Rose Bengal or a functional derivative of Rose Bengal.

Diagnostic agents for positron emission imaging using radiolabeled halogenated xanthenes

High energy phototherapeutic agents or radiosensitizer agents comprised of a halogenated xanthene, or other related agents that exhibit a preference for concentration in biologically sensitive structures in diseased tissue, and methods of treating and imaging using such radiosensitizer agents in such diseased tissue are described herein.

High energy phototherapeutic agents

Methods for positron emission imaging with radiolabeled halogenated xanthenes diagnostic agents

New contrast agents for ultrasound imaging and methods for use of such agents for imaging of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. Preferably, the halogenated xanthene is Rose Bengal or a functional derivative of Rose Bengal.

Ultrasound contrast using halogenated xanthenes

Growing community of inventors

Knoxville, TN, United States of America

Timothy C Scott