Globeimmune, Inc.

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Rxkinetix, Inc.

Endo Pharmaceuticals Colorado, Inc.

Timothy C Rodell

David Apelian

Gary Joseph Rosenthal

Wren Henderson Schauer

Jeffrey Schlom

Alex Franzusoff

Jeffrey B Etter

Claudia M Palena

Claire Coeshott

Adrian C Samaniego

Joan P Blonder

One embodiment of the invention relates to a method to treat chordoma in an individual who has chordoma. The method includes the step of administering to an individual who has chordoma, an immunotherapeutic composition comprising: (a) a yeast vehicle; and (b) a cancer antigen comprising at least one Brachyury antigen. Another embodiment of the invention relates to the use of an immunotherapeutic composition comprising a yeast vehicle and a cancer antigen comprising at least one Brachyury antigen to chordoma in an individual who has chordoma. Yet another embodiment of the invention relates to the use an immunotherapeutic composition comprising a yeast vehicle.

Yeast-based immunotherapy for Chordoma

Provided herein are compositions and methods for targeted ablation of mutational escape in the face of cancer therapeutic agents. Compositions comprising the yeast-based vehicles are used in combination with other cancer therapeutic agents.

Compositions and methods for targeted ablation of mutational escape of targeted therapies for cancer

The present invention provides an immunogen composition and methods for using the same for the development of immunity, and particularly at mucosal sites in a mammal, thereby providing immunity at the site of entry for many major pathogenic organisms and also systemic immunity. The immunogen composition includes an antigen, a biocompatible polymer, and a liquid vehicle, with the biocompatible polymer and liquid vehicle being present in such proportions and interacting in such a way that the immunogen composition exhibits reverse-thermal viscosity behaviour. A delivery vehicle composition including a drug other than an antigen is also provided. Methods are provided for delivering the compositions of the invention to a host.

Delivery vehicle composition and methods for delivering antigens and other drugs

This present invention provides a therapeutic composition for use in the treatment of mucositis and a method for using such a therapeutic composition. The therapeutic composition includes a pharmaceutical substance effective for treating mucositis formulated with a biocompatible polymer, such as a biocompatible reverse-thermal gelation polymer.

Treatment of mucositis

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Aspen, CO, United States of America

Timothy C Rodell